| Reaction Details |
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 | Report a problem with these data |
| Target | 4,4'-diapophytoene synthase |
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| Ligand | BDBM50049229 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_494370 (CHEMBL941163) |
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| IC50 | 72400±n/a nM |
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| Citation |  Song, Y; Lin, FY; Yin, F; Hensler, M; Rodrígues Poveda, CA; Mukkamala, D; Cao, R; Wang, H; Morita, CT; González Pacanowska, D; Nizet, V; Oldfield, E Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem52:976-88 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 4,4'-diapophytoene synthase |
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| Name: | 4,4'-diapophytoene synthase |
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| Synonyms: | CRTM_STAAU | Dehydrosqualene synthase | crtM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34309.10 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_1352846 |
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| Residue: | 287 |
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| Sequence: | MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFL
NQIKEDIQSIEKYPYEYHHFQSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMF
ETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRLGESLQLINILRDVGEDFENE
RIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFRDVMDQIKVFSIEAQPI
IELAARIYIEILDEVRQANYTLHERVFVEKRKKAKLFHEINSKYHRI
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| BDBM50049229 |
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| n/a |
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| Name | BDBM50049229 |
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| Synonyms: | 1-Phosphono-4-[4-(4-butylphenyl)phenyl]butylsulfonic Acid Tripotassium Salt | CHEMBL158844 | Tripotassium salt of 4-(4'-Butyl-biphenyl-4-yl)-1-phosphono-butane-1-sulfonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24O6PS |
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| Mol. Mass. | 423.441 |
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| SMILES | CCCCc1ccc(cc1)-c1ccc(CCCC(P([O-])([O-])=O)S([O-])(=O)=O)cc1 |
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| Structure | 
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