Reaction Details |
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Target | Tyrosine-protein kinase ZAP-70 |
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Ligand | BDBM4811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_591751 (CHEMBL1037893) |
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IC50 | 28400±n/a nM |
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Citation | Sanam, R; Vadivelan, S; Tajne, S; Narasu, L; Rambabu, G; Jagarlapudi, SA Discovery of potential ZAP-70 kinase inhibitors: pharmacophore design, database screening and docking studies. Eur J Med Chem44:4793-800 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ZAP-70 |
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Name: | Tyrosine-protein kinase ZAP-70 |
Synonyms: | 70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa |
Type: | Enzyme |
Mol. Mass.: | 69881.61 |
Organism: | Homo sapiens (Human) |
Description: | ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column. |
Residue: | 619 |
Sequence: | MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
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BDBM4811 |
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n/a |
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Name | BDBM4811 |
Synonyms: | (Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid | 3-(2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid | CHEMBL274654 | SU6668 |
Type | Small organic molecule |
Emp. Form. | C18H18N2O3 |
Mol. Mass. | 310.3471 |
SMILES | Cc1[nH]c(\C=C2/C(=O)Nc3ccccc23)c(C)c1CCC(O)=O |
Structure |
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