| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
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| Ligand | BDBM50308532 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_613466 (CHEMBL1070174) |
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| IC50 | 11000±n/a nM |
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| Citation |  Arai, H; Hirasawa, Y; Rahman, A; Kusumawati, I; Zaini, NC; Sato, S; Aoyama, C; Takeo, J; Morita, H Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem18:2152-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/glucose cotransporter 2 |
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| Name: | Sodium/glucose cotransporter 2 |
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| Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
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| Type: | Protein |
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| Mol. Mass.: | 72902.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31639 |
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| Residue: | 672 |
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| Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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| BDBM50308532 |
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| n/a |
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| Name | BDBM50308532 |
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| Synonyms: | (14E)-14-ethylidene-6-methoxy-19-(methoxycarbonyl)-2-methyl-19-{[(3,4,5-trimethoxyphenyl)carbonyloxy]methyl}-18-oxa-2,12-diazahexacyclo[9.6.1.1^{9,15}.0^{1,9}.0^{3,8}.0^{12,17}]nonadeca-3(8),4,6-trien-12-ium-12-olate | CHEMBL602444 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H38N2O10 |
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| Mol. Mass. | 622.6622 |
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| SMILES | COC(=O)[C@]1(COC(=O)c2cc(OC)c(OC)c(OC)c2)[C@H]2C[C@H]3[C@]45O[C@@H](C[C@]14c1cc(OC)ccc1N5C)[N+]3([O-])C\C2=C\C |r| |
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| Structure | 
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