| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase, cytosolic |
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| Ligand | BDBM50314850 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_627481 (CHEMBL1111767) |
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| IC50 | 316000±n/a nM |
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| Citation |  Van Poecke, S; Negri, A; Gago, F; Van Daele, I; Solaroli, N; Karlsson, A; Balzarini, J; Van Calenbergh, S 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem53:2902-12 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase, cytosolic |
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| Name: | Thymidine kinase, cytosolic |
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| Synonyms: | KITH_HUMAN | TK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 25476.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1333884 |
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| Residue: | 234 |
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| Sequence: | MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
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| BDBM50314850 |
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| n/a |
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| Name | BDBM50314850 |
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| Synonyms: | 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-((2S,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)thiourea | CHEMBL1091873 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClF3N4O4S |
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| Mol. Mass. | 478.873 |
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| SMILES | Cc1cn([C@H]2C[C@H](NC(=S)Nc3ccc(Cl)c(c3)C(F)(F)F)[C@@H](CO)O2)c(=O)[nH]c1=O |r| |
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| Structure | 
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