| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 11 |
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| Ligand | BDBM50315132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_624924 (CHEMBL1107047) |
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| IC50 | 1050±n/a nM |
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| Citation |  Walker, JK; Selness, SR; Devraj, RV; Hepperle, ME; Naing, W; Shieh, H; Kurambail, R; Yang, S; Flynn, DL; Benson, AG; Messing, DM; Dice, T; Kim, T; Lindmark, RJ; Monahan, JB; Portanova, J Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett20:2634-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 11 |
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| Name: | Mitogen-activated protein kinase 11 |
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| Synonyms: | MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41351.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_20128774 |
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| Residue: | 364 |
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| Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
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| BDBM50315132 |
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| n/a |
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| Name | BDBM50315132 |
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| Synonyms: | 4-(3-(3-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyridine | CHEMBL1092903 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21ClN4 |
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| Mol. Mass. | 352.861 |
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| SMILES | CN1CCC(CC1)c1[nH]nc(c1-c1ccncc1)-c1cccc(Cl)c1 |
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| Structure | 
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