Compile Data Set for Download or QSAR

Found 268 hits with Last Name = 'monahan' and Initial = 'jb'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50346920 (CHEMBL1795686) Show SMILES CCc1c(OCc2ccc(F)cc2F)ncn(-c2cc(ccc2C)C(=O)NCCO)c1=O Show InChI InChI=1S/C23H23F2N3O4/c1-3-18-22(32-12-16-6-7-17(24)11-19(16)25)27-13-28(23(18)31)20-10-15(5-4-14(20)2)21(30)26-8-9-29/h4-7,10-11,13,29H,3,8-9,12H2,1-2H3,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38beta kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50346919 (CHEMBL1795685) Show SMILES Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(C)c1=O)C(=O)NCCO Show InChI InChI=1S/C22H21F2N3O4/c1-13-3-4-15(20(29)25-7-8-28)9-19(13)27-12-26-21(14(2)22(27)30)31-11-16-5-6-17(23)10-18(16)24/h3-6,9-10,12,28H,7-8,11H2,1-2H3,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38beta kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38beta kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50346918 (CHEMBL1738710) Show SMILES Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(=O)NCCO Show InChI InChI=1S/C21H18ClF2N3O4/c1-12-2-3-13(19(29)25-6-7-28)8-17(12)27-11-26-20(18(22)21(27)30)31-10-14-4-5-15(23)9-16(14)24/h2-5,8-9,11,28H,6-7,10H2,1H3,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	193	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of JNK2				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347099 (CHEMBL1797202) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(Cl)cccc1Cl |(3.97,-20.05,;2.63,-20.81,;1.31,-20.04,;-.02,-20.81,;-1.36,-20.05,;-2.69,-20.82,;-4.03,-20.06,;-5.35,-20.83,;-6.68,-20.07,;-6.69,-18.52,;-8.03,-17.76,;-5.36,-17.75,;-4.02,-18.52,;-2.69,-17.75,;-.02,-22.35,;-1.36,-23.13,;1.31,-23.12,;1.31,-24.66,;2.63,-22.35,;3.97,-23.13,;5.29,-22.36,;5.29,-20.82,;6.62,-23.12,;6.63,-24.67,;5.29,-25.44,;3.96,-24.67,;2.62,-25.43,)| Show InChI InChI=1S/C19H12BrCl2F2NO2/c1-10-7-16(27-9-11-5-6-12(23)8-15(11)24)17(20)19(26)25(10)18-13(21)3-2-4-14(18)22/h2-8H,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cells				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347100 (CHEMBL1797203) Show SMILES Cc1cccc(C)c1-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.24,-20.12,;29.24,-21.66,;30.57,-22.42,;30.57,-23.97,;29.24,-24.74,;27.91,-23.97,;26.57,-24.73,;27.92,-22.43,;26.58,-21.65,;26.58,-20.11,;27.92,-19.35,;25.25,-19.34,;23.92,-20.11,;22.59,-19.35,;21.26,-20.12,;19.92,-19.36,;18.6,-20.13,;17.27,-19.37,;17.26,-17.82,;15.92,-17.06,;18.59,-17.05,;19.92,-17.82,;21.26,-17.05,;23.92,-21.65,;22.59,-22.43,;25.25,-22.42,;25.25,-23.96,)| Show InChI InChI=1S/C21H18BrF2NO2/c1-12-5-4-6-13(2)20(12)25-14(3)9-18(19(22)21(25)26)27-11-15-7-8-16(23)10-17(15)24/h4-10H,11H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347929 (CHEMBL1802632) Show SMILES Cc1ccc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O)C(N)=O |(3.55,-6.94,;3.56,-8.48,;4.89,-9.25,;4.9,-10.79,;3.56,-11.57,;2.23,-10.8,;2.24,-9.26,;.9,-8.49,;.9,-6.94,;2.23,-6.16,;-.44,-6.17,;-1.77,-6.95,;-3.1,-6.18,;-4.44,-6.95,;-5.77,-6.18,;-7.09,-6.95,;-8.43,-6.18,;-8.43,-4.64,;-9.77,-3.87,;-7.1,-3.87,;-5.76,-4.64,;-4.43,-3.87,;-1.77,-8.49,;-3.1,-9.26,;-.44,-9.26,;-.44,-10.8,;3.56,-13.11,;4.9,-13.87,;2.23,-13.88,)| Show InChI InChI=1S/C21H17BrF2N2O3/c1-11-3-4-13(20(25)27)8-17(11)26-12(2)7-18(19(22)21(26)28)29-10-14-5-6-15(23)9-16(14)24/h3-9H,10H2,1-2H3,(H2,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347938 (CHEMBL1802637) Show SMILES CNC(=O)c1ccc(Cl)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(35.79,-26.5,;35.75,-24.96,;37.07,-24.16,;38.42,-24.9,;37.04,-22.63,;38.37,-21.85,;38.37,-20.31,;37.03,-19.54,;37.02,-18,;35.71,-20.32,;35.71,-21.86,;34.38,-19.55,;34.37,-18,;35.7,-17.22,;33.04,-17.23,;31.71,-18.01,;30.37,-17.24,;29.04,-18.01,;27.71,-17.24,;26.38,-18.01,;25.05,-17.24,;25.04,-15.7,;23.71,-14.93,;26.38,-14.93,;27.71,-15.7,;29.05,-14.93,;31.71,-19.55,;30.37,-20.32,;33.04,-20.32,;33.04,-21.86,)| Show InChI InChI=1S/C21H16BrClF2N2O3/c1-11-7-18(30-10-13-3-5-14(24)9-16(13)25)19(22)21(29)27(11)17-8-12(20(28)26-2)4-6-15(17)23/h3-9H,10H2,1-2H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347096 (CHEMBL1797123) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cccc1F |(2.41,3.39,;1.07,2.62,;-.26,3.4,;-1.59,2.62,;-2.92,3.39,;-4.25,2.61,;-5.59,3.38,;-6.91,2.6,;-8.25,3.36,;-8.26,4.91,;-9.59,5.67,;-6.92,5.68,;-5.59,4.92,;-4.25,5.69,;-1.59,1.08,;-2.92,.31,;-.26,.32,;-.26,-1.22,;1.07,1.08,;2.4,.31,;3.73,1.08,;3.73,2.62,;5.06,.31,;5.06,-1.23,;3.73,-2,;2.4,-1.23,;1.06,-2,)| Show InChI InChI=1S/C19H12BrF4NO2/c1-10-7-16(27-9-11-5-6-12(21)8-15(11)24)17(20)19(26)25(10)18-13(22)3-2-4-14(18)23/h2-8H,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347106 (CHEMBL1797209) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cc(OCC(N)=O)cc1F |(24.13,3.5,;22.79,2.74,;21.47,3.52,;20.14,2.74,;18.8,3.5,;17.47,2.73,;16.13,3.5,;14.81,2.72,;13.48,3.48,;13.47,5.03,;12.13,5.79,;14.8,5.8,;16.14,5.03,;17.47,5.8,;20.14,1.2,;18.8,.43,;21.47,.44,;21.47,-1.1,;22.79,1.2,;24.13,.43,;25.45,1.19,;25.45,2.73,;26.78,.43,;26.79,-1.12,;28.12,-1.89,;29.45,-1.12,;30.79,-1.89,;32.12,-1.12,;30.79,-3.43,;25.45,-1.89,;24.12,-1.11,;22.78,-1.88,)| Show InChI InChI=1S/C21H15BrF4N2O4/c1-10-4-17(32-8-11-2-3-12(23)5-14(11)24)19(22)21(30)28(10)20-15(25)6-13(7-16(20)26)31-9-18(27)29/h2-7H,8-9H2,1H3,(H2,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347937 (CHEMBL1802641) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(CO)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(2.58,-49.12,;2.54,-47.58,;3.86,-46.78,;5.21,-47.52,;3.83,-45.24,;5.16,-44.47,;5.15,-42.92,;3.82,-42.16,;3.81,-40.62,;2.5,-42.93,;2.49,-44.48,;1.17,-42.17,;1.16,-40.62,;2.49,-39.84,;2.49,-38.3,;-.17,-39.85,;-1.5,-40.62,;-2.84,-39.85,;-4.17,-40.62,;-5.5,-39.85,;-6.83,-40.62,;-8.16,-39.86,;-8.17,-38.31,;-9.5,-37.55,;-6.83,-37.54,;-5.5,-38.31,;-4.16,-37.55,;-1.51,-42.17,;-2.84,-42.94,;-.17,-42.94,;-.17,-44.48,)| Show InChI InChI=1S/C22H19BrF2N2O4/c1-12-3-4-13(21(29)26-2)7-18(12)27-16(10-28)9-19(20(23)22(27)30)31-11-14-5-6-15(24)8-17(14)25/h3-9,28H,10-11H2,1-2H3,(H,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347126 (CHEMBL1797124) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1c(F)cccc1F |(27.98,3.45,;26.64,2.68,;25.32,3.46,;23.99,2.68,;22.65,3.45,;21.32,2.68,;19.98,3.44,;18.66,2.66,;17.33,3.42,;17.32,4.97,;15.98,5.74,;18.65,5.75,;19.99,4.98,;21.32,5.75,;23.99,1.14,;22.65,.37,;25.32,.38,;25.32,-1.16,;26.64,1.14,;27.98,.37,;29.3,1.14,;29.3,2.68,;30.63,.38,;30.64,-1.17,;29.3,-1.94,;27.97,-1.17,;26.63,-1.93,)| Show InChI InChI=1S/C19H12ClF4NO2/c1-10-7-16(27-9-11-5-6-12(21)8-15(11)24)17(20)19(26)25(10)18-13(22)3-2-4-14(18)23/h2-8H,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347107 (CHEMBL1797210) Show SMILES OCc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cccc1F |(3.15,-8.82,;3.15,-10.36,;1.81,-11.13,;.48,-10.35,;-.85,-11.13,;-2.18,-10.36,;-3.52,-11.14,;-4.85,-10.37,;-6.17,-11.15,;-7.51,-10.39,;-7.52,-8.84,;-8.85,-8.08,;-6.18,-8.07,;-4.85,-8.83,;-3.51,-8.06,;-.85,-12.67,;-2.18,-13.44,;.48,-13.43,;.48,-14.97,;1.81,-12.67,;3.14,-13.44,;4.47,-12.67,;4.46,-11.13,;5.8,-13.44,;5.8,-14.99,;4.47,-15.75,;3.13,-14.98,;1.8,-15.75,)| Show InChI InChI=1S/C19H12BrF4NO3/c20-17-16(28-9-10-4-5-11(21)6-15(10)24)7-12(8-26)25(19(17)27)18-13(22)2-1-3-14(18)23/h1-7,26H,8-9H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347098 (CHEMBL1797201) Show SMILES Cc1cc(OCc2ccc(F)cc2)c(Br)c(=O)n1-c1c(Cl)cccc1Cl |(28.09,-8.26,;26.75,-9.03,;25.42,-8.25,;24.1,-9.03,;22.76,-8.26,;21.43,-9.04,;20.09,-8.27,;20.1,-6.73,;18.76,-5.97,;17.43,-6.74,;16.09,-5.98,;17.44,-8.29,;18.77,-9.05,;24.1,-10.57,;22.76,-11.34,;25.42,-11.33,;25.42,-12.87,;26.75,-10.57,;28.09,-11.34,;29.41,-10.57,;29.41,-9.03,;30.74,-11.34,;30.75,-12.89,;29.41,-13.65,;28.08,-12.88,;26.74,-13.65,)| Show InChI InChI=1S/C19H13BrCl2FNO2/c1-11-9-16(26-10-12-5-7-13(23)8-6-12)17(20)19(25)24(11)18-14(21)3-2-4-15(18)22/h2-9H,10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347109 (CHEMBL1797212) Show SMILES CN(C)Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cccc1F |(3.68,-20.77,;2.34,-21.54,;1.01,-20.77,;2.34,-23.08,;1,-23.85,;-.33,-23.07,;-1.66,-23.85,;-2.99,-23.08,;-4.32,-23.85,;-5.66,-23.09,;-6.98,-23.87,;-8.32,-23.11,;-8.32,-21.56,;-9.66,-20.79,;-6.99,-20.78,;-5.66,-21.55,;-4.32,-20.78,;-1.66,-25.39,;-2.99,-26.16,;-.33,-26.15,;-.33,-27.69,;1,-25.39,;2.33,-26.16,;3.66,-25.39,;3.65,-23.85,;4.99,-26.15,;4.99,-27.7,;3.66,-28.47,;2.33,-27.7,;.99,-28.46,)| Show InChI InChI=1S/C21H17BrF4N2O2/c1-27(2)10-14-9-18(30-11-12-6-7-13(23)8-17(12)26)19(22)21(29)28(14)20-15(24)4-3-5-16(20)25/h3-9H,10-11H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50346924 (CHEMBL1795684) Show SMILES C[C@@H](NC(=O)c1ccc(C)c(c1)-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(N)=O |r| Show InChI InChI=1S/C22H19ClF2N4O4/c1-11-3-4-13(20(31)28-12(2)19(26)30)7-17(11)29-10-27-21(18(23)22(29)32)33-9-14-5-6-15(24)8-16(14)25/h3-8,10,12H,9H2,1-2H3,(H2,26,30)(H,28,31)/t12-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cells				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM235961 (US9365546, 284) Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,5.39,;,4.62,;,3.08,;1.33,2.31,;2.67,3.08,;4,2.31,;2.67,4.62,;1.33,5.39,;1.33,6.93,;-4,2.31,;-5.33,3.08,;-4,.77,;-5.33,,;,-4.62,;,-6.16,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;4,-3.85,;3.23,-2.52,;4.77,-2.52,;5.33,-4.62,)| Show InChI InChI=1S/C26H23ClF2N4O3/c1-14-12-31-20(19-7-8-30-25(32-19)26(3,4)35)11-21(14)33-15(2)9-22(23(27)24(33)34)36-13-16-5-6-17(28)10-18(16)29/h5-12,35H,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	7.5	25
CONFLUENCE LIFE SCIENCES INC. US Patent					Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...				US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347105 (CHEMBL1797208) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cc(OCCO)cc1F |(2.39,2.52,;1.06,1.75,;-.27,2.53,;-1.6,1.75,;-2.94,2.52,;-4.27,1.74,;-5.61,2.51,;-6.93,1.73,;-8.26,2.49,;-8.27,4.04,;-9.61,4.8,;-6.94,4.81,;-5.6,4.05,;-4.27,4.82,;-1.6,.21,;-2.93,-.56,;-.27,-.55,;-.27,-2.09,;1.06,.21,;2.39,-.56,;3.71,.21,;3.71,1.75,;5.05,-.56,;5.05,-2.11,;6.38,-2.88,;7.72,-2.11,;9.05,-2.88,;10.38,-2.11,;3.71,-2.87,;2.38,-2.1,;1.04,-2.87,)| Show InChI InChI=1S/C21H16BrF4NO4/c1-11-6-18(31-10-12-2-3-13(23)7-15(12)24)19(22)21(29)27(11)20-16(25)8-14(9-17(20)26)30-5-4-28/h2-3,6-9,28H,4-5,10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM235961 (US9365546, 284) Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,5.39,;,4.62,;,3.08,;1.33,2.31,;2.67,3.08,;4,2.31,;2.67,4.62,;1.33,5.39,;1.33,6.93,;-4,2.31,;-5.33,3.08,;-4,.77,;-5.33,,;,-4.62,;,-6.16,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;4,-3.85,;3.23,-2.52,;4.77,-2.52,;5.33,-4.62,)| Show InChI InChI=1S/C26H23ClF2N4O3/c1-14-12-31-20(19-7-8-30-25(32-19)26(3,4)35)11-21(14)33-15(2)9-22(23(27)24(33)34)36-13-16-5-6-17(28)10-18(16)29/h5-12,35H,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	7.5	25
CONFLUENCE LIFE SCIENCES INC. US Patent					Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...				US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347103 (CHEMBL1797206) Show SMILES CN(C)c1cc(F)c(c(F)c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(6.77,-50.31,;6.78,-48.77,;8.1,-47.99,;5.44,-48,;5.44,-46.45,;4.11,-45.69,;4.11,-44.15,;2.79,-46.46,;2.78,-48,;1.44,-48.76,;4.11,-48.77,;1.45,-45.69,;1.45,-44.15,;2.79,-43.38,;.12,-43.37,;-1.21,-44.15,;-2.54,-43.38,;-3.87,-44.15,;-5.21,-43.39,;-6.53,-44.17,;-7.86,-43.41,;-7.87,-41.86,;-9.21,-41.09,;-6.54,-41.08,;-5.21,-41.85,;-3.87,-41.08,;-1.21,-45.69,;-2.54,-46.46,;.12,-46.45,;.12,-47.99,)| Show InChI InChI=1S/C21H17BrF4N2O2/c1-11-6-18(30-10-12-4-5-13(23)7-15(12)24)19(22)21(29)28(11)20-16(25)8-14(27(2)3)9-17(20)26/h4-9H,10H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347108 (CHEMBL1797211) Show SMILES OCc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1c(F)cccc1F |(28.8,-8.57,;28.8,-10.11,;27.46,-10.87,;26.13,-10.1,;24.8,-10.87,;23.47,-10.11,;22.14,-10.88,;20.8,-10.12,;19.48,-10.89,;18.14,-10.13,;18.14,-8.58,;16.8,-7.82,;19.47,-7.81,;20.8,-8.58,;22.14,-7.81,;24.8,-12.41,;23.47,-13.19,;26.13,-13.18,;26.13,-14.72,;27.46,-12.41,;28.79,-13.19,;30.12,-12.42,;30.11,-10.88,;31.45,-13.18,;31.45,-14.73,;30.12,-15.5,;28.79,-14.73,;27.45,-15.49,)| Show InChI InChI=1S/C19H12ClF4NO3/c20-17-16(28-9-10-4-5-11(21)6-15(10)24)7-12(8-26)25(19(17)27)18-13(22)2-1-3-14(18)23/h1-7,26H,8-9H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347110 (CHEMBL1797213) Show SMILES CN(C)Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1c(F)cccc1F |(29.59,-20.31,;28.25,-21.07,;26.92,-20.3,;28.25,-22.61,;26.91,-23.38,;25.58,-22.6,;24.25,-23.38,;22.92,-22.61,;21.58,-23.39,;20.25,-22.62,;18.93,-23.4,;17.59,-22.64,;17.58,-21.09,;16.25,-20.33,;18.92,-20.32,;20.25,-21.08,;21.58,-20.31,;24.25,-24.92,;22.92,-25.69,;25.58,-25.68,;25.58,-27.22,;26.91,-24.92,;28.24,-25.69,;29.57,-24.92,;29.56,-23.38,;30.9,-25.69,;30.9,-27.24,;29.56,-28,;28.23,-27.23,;26.9,-28,)| Show InChI InChI=1S/C21H17ClF4N2O2/c1-27(2)10-14-9-18(30-11-12-6-7-13(23)8-17(12)26)19(22)21(29)28(14)20-15(24)4-3-5-16(20)25/h3-9H,10-11H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347933 (CHEMBL1802636) Show SMILES CNC(=O)c1ccc(F)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(21.06,-26.62,;21.02,-25.08,;22.34,-24.28,;23.69,-25.02,;22.31,-22.75,;23.64,-21.98,;23.63,-20.43,;22.3,-19.67,;22.29,-18.13,;20.98,-20.44,;20.97,-21.98,;19.65,-19.67,;19.64,-18.12,;20.97,-17.35,;18.31,-17.36,;16.98,-18.13,;15.64,-17.36,;14.31,-18.13,;12.98,-17.36,;11.65,-18.13,;10.32,-17.37,;10.31,-15.82,;8.98,-15.05,;11.65,-15.05,;12.98,-15.82,;14.32,-15.05,;16.97,-19.67,;15.64,-20.44,;18.31,-20.45,;18.31,-21.99,)| Show InChI InChI=1S/C21H16BrF3N2O3/c1-11-7-18(30-10-13-3-5-14(23)9-16(13)25)19(22)21(29)27(11)17-8-12(20(28)26-2)4-6-15(17)24/h3-9H,10H2,1-2H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347111 (CHEMBL1797214) Show SMILES Fc1ccc(COc2cc(CN3CCOCC3)n(-c3c(F)cccc3F)c(=O)c2Br)c(F)c1 |(-9.72,-33.39,;-8.38,-34.16,;-8.37,-35.71,;-7.03,-36.47,;-5.71,-35.69,;-4.38,-36.45,;-3.05,-35.68,;-1.71,-36.45,;-.38,-35.67,;.95,-36.45,;2.28,-35.68,;2.29,-34.14,;3.62,-33.38,;3.63,-31.85,;2.3,-31.07,;.96,-31.83,;.95,-33.37,;.95,-37.99,;2.28,-38.76,;3.6,-37.99,;3.6,-36.45,;4.94,-38.75,;4.94,-40.3,;3.6,-41.07,;2.27,-40.3,;.94,-41.06,;-.38,-38.75,;-.38,-40.29,;-1.71,-37.99,;-3.04,-38.76,;-5.71,-34.15,;-4.38,-33.38,;-7.05,-33.38,)| Show InChI InChI=1S/C23H19BrF4N2O3/c24-21-20(33-13-14-4-5-15(25)10-19(14)28)11-16(12-29-6-8-32-9-7-29)30(23(21)31)22-17(26)2-1-3-18(22)27/h1-5,10-11H,6-9,12-13H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347930 (CHEMBL1802633) Show SMILES CN(C)C(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(19.71,-15.18,;19.71,-13.64,;21.04,-12.87,;18.37,-12.87,;17.04,-13.64,;18.37,-11.33,;19.71,-10.56,;19.7,-9.01,;18.36,-8.25,;18.36,-6.71,;17.05,-9.02,;17.04,-10.56,;15.71,-8.26,;15.7,-6.71,;17.04,-5.93,;14.37,-5.94,;13.04,-6.71,;11.71,-5.94,;10.37,-6.71,;9.04,-5.94,;7.72,-6.71,;6.38,-5.95,;6.38,-4.4,;5.04,-3.63,;7.71,-3.63,;9.05,-4.4,;10.38,-3.63,;13.04,-8.26,;11.7,-9.03,;14.37,-9.03,;14.37,-10.57,)| Show InChI InChI=1S/C23H21BrF2N2O3/c1-13-5-6-15(22(29)27(3)4)10-19(13)28-14(2)9-20(21(24)23(28)30)31-12-16-7-8-17(25)11-18(16)26/h5-11H,12H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50346920 (CHEMBL1795686) Show SMILES CCc1c(OCc2ccc(F)cc2F)ncn(-c2cc(ccc2C)C(=O)NCCO)c1=O Show InChI InChI=1S/C23H23F2N3O4/c1-3-18-22(32-12-16-6-7-17(24)11-19(16)25)27-13-28(23(18)31)20-10-15(5-4-14(20)2)21(30)26-8-9-29/h4-7,10-11,13,29H,3,8-9,12H2,1-2H3,(H,26,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cells				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347121 (CHEMBL1797224) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1cccc(c1)C(N)=O Show InChI InChI=1S/C20H15BrF2N2O3/c1-11-7-17(28-10-13-5-6-14(22)9-16(13)23)18(21)20(27)25(11)15-4-2-3-12(8-15)19(24)26/h2-9H,10H2,1H3,(H2,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347121 (CHEMBL1797224) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1cccc(c1)C(N)=O Show InChI InChI=1S/C20H15BrF2N2O3/c1-11-7-17(28-10-13-5-6-14(22)9-16(13)23)18(21)20(27)25(11)15-4-2-3-12(8-15)19(24)26/h2-9H,10H2,1H3,(H2,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19440 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES CC1CN(CC(C)N1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22ClN5/c1-13-11-26(12-14(2)23-13)20-18(15-7-9-22-10-8-15)19(24-25-20)16-3-5-17(21)6-4-16/h3-10,13-14,23H,11-12H2,1-2H3,(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50346918 (CHEMBL1738710) Show SMILES Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(=O)NCCO Show InChI InChI=1S/C21H18ClF2N3O4/c1-12-2-3-13(19(29)25-6-7-28)8-17(12)27-11-26-20(18(22)21(27)30)31-10-14-4-5-15(23)9-16(14)24/h2-5,8-9,11,28H,6-7,10H2,1H3,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cells				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50346923 (CHEMBL1795683) Show SMILES C[C@H](CO)CNC(=O)c1ccc(C)c(c1)-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O |r| Show InChI InChI=1S/C23H22ClF2N3O4/c1-13(10-30)9-27-21(31)15-4-3-14(2)19(7-15)29-12-28-22(20(24)23(29)32)33-11-16-5-6-17(25)8-18(16)26/h3-8,12-13,30H,9-11H2,1-2H3,(H,27,31)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cells				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347101 (CHEMBL1797204) Show SMILES CN1CCN(CC1)c1cc(F)c(c(F)c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(9.91,-37.66,;8.58,-36.88,;7.24,-37.65,;5.91,-36.88,;5.92,-35.34,;7.25,-34.56,;8.58,-35.34,;4.59,-34.57,;4.59,-33.02,;3.25,-32.26,;3.25,-30.72,;1.93,-33.03,;1.92,-34.57,;.59,-35.33,;3.25,-35.34,;.6,-32.25,;.6,-30.71,;1.93,-29.95,;-.73,-29.94,;-2.06,-30.71,;-3.4,-29.95,;-4.73,-30.72,;-6.06,-29.96,;-7.38,-30.73,;-8.72,-29.97,;-8.73,-28.43,;-10.07,-27.66,;-7.4,-27.65,;-6.06,-28.42,;-4.73,-27.65,;-2.06,-32.25,;-3.39,-33.03,;-.73,-33.02,;-.73,-34.56,)| Show InChI InChI=1S/C24H22BrF4N3O2/c1-14-9-21(34-13-15-3-4-16(26)10-18(15)27)22(25)24(33)32(14)23-19(28)11-17(12-20(23)29)31-7-5-30(2)6-8-31/h3-4,9-12H,5-8,13H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50315107 (4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES NS(=O)(=O)N1CCC(CC1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClN5O2S/c20-16-3-1-14(2-4-16)18-17(13-5-9-22-10-6-13)19(24-23-18)15-7-11-25(12-8-15)28(21,26)27/h1-6,9-10,15H,7-8,11-12H2,(H,23,24)(H2,21,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation counting				Bioorg Med Chem Lett 20: 2634-8 (2010) Article DOI: 10.1016/j.bmcl.2010.02.047 BindingDB Entry DOI: 10.7270/Q21N818H
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347104 (CHEMBL1797207) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1c(F)cc(O)cc1F |(26.27,-43.79,;24.93,-44.55,;23.6,-43.77,;22.28,-44.55,;20.94,-43.79,;19.61,-44.56,;18.27,-43.79,;16.95,-44.57,;15.62,-43.81,;15.61,-42.26,;14.27,-41.5,;16.94,-41.49,;18.28,-42.25,;19.61,-41.48,;22.28,-46.09,;20.94,-46.86,;23.6,-46.85,;23.6,-48.39,;24.93,-46.09,;26.27,-46.86,;27.59,-46.09,;27.59,-44.55,;28.92,-46.86,;28.93,-48.41,;30.26,-49.18,;27.59,-49.17,;26.26,-48.4,;24.92,-49.17,)| Show InChI InChI=1S/C19H12BrF4NO3/c1-9-4-16(28-8-10-2-3-11(21)5-13(10)22)17(20)19(27)25(9)18-14(23)6-12(26)7-15(18)24/h2-7,26H,8H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347116 (CHEMBL1797219) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1ccc(CNC(=O)CN)cc1 Show InChI InChI=1S/C22H20BrF2N3O3/c1-13-8-19(31-12-15-4-5-16(24)9-18(15)25)21(23)22(30)28(13)17-6-2-14(3-7-17)11-27-20(29)10-26/h2-9H,10-12,26H2,1H3,(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19439 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES CC1CN(CCN1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClN5/c1-13-12-25(11-10-22-13)19-17(14-6-8-21-9-7-14)18(23-24-19)15-2-4-16(20)5-3-15/h2-9,13,22H,10-12H2,1H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347123 (CHEMBL1797226) Show SMILES CNC(=O)c1cccc(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O Show InChI InChI=1S/C21H17BrF2N2O3/c1-12-8-18(29-11-14-6-7-15(23)10-17(14)24)19(22)21(28)26(12)16-5-3-4-13(9-16)20(27)25-2/h3-10H,11H2,1-2H3,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50314073 (3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...) Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase in human monocytes				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50346918 (CHEMBL1738710) Show SMILES Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(=O)NCCO Show InChI InChI=1S/C21H18ClF2N3O4/c1-12-2-3-13(19(29)25-6-7-28)8-17(12)27-11-26-20(18(22)21(27)30)31-10-14-4-5-15(23)9-16(14)24/h2-5,8-9,11,28H,6-7,10H2,1H3,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha kinase in human monocytes				Bioorg Med Chem Lett 21: 3856-60 (2011) Article DOI: 10.1016/j.bmcl.2011.05.006 BindingDB Entry DOI: 10.7270/Q2G73F2S
					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM235962 (US9365546, 285) Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)C |(-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,5.39,;,4.62,;,3.08,;1.33,2.31,;2.67,3.08,;4,2.31,;2.67,4.62,;1.33,5.39,;1.33,6.93,;-4,2.31,;-5.33,3.08,;-4,.77,;-5.33,,;,-4.62,;,-6.16,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;4,-3.85,;5.33,-4.62,;3.23,-2.52,;4.77,-2.52,)| Show InChI InChI=1S/C27H25ClF2N4O2/c1-15-13-32-21(20-8-9-31-26(33-20)27(3,4)5)12-22(15)34-16(2)10-23(24(28)25(34)35)36-14-17-6-7-18(29)11-19(17)30/h6-13H,14H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	25
CONFLUENCE LIFE SCIENCES INC. US Patent					Assay Description Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...				US Patent US9365546 (2016) BindingDB Entry DOI: 10.7270/Q2XK8DFP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50315120 ((1S,2S)-2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl...) Show SMILES O[C@H]1CCC[C@@H]1N1CCC(CC1)c1[nH]nc(c1-c1ccncn1)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C23H26ClN5O/c24-17-6-4-15(5-7-17)22-21(18-8-11-25-14-26-18)23(28-27-22)16-9-12-29(13-10-16)19-2-1-3-20(19)30/h4-8,11,14,16,19-20,30H,1-3,9-10,12-13H2,(H,27,28)/t19-,20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation counting				Bioorg Med Chem Lett 20: 2634-8 (2010) Article DOI: 10.1016/j.bmcl.2010.02.047 BindingDB Entry DOI: 10.7270/Q21N818H
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347114 (CHEMBL1797217) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1ccc(CNC(=O)CO)cc1 Show InChI InChI=1S/C22H19BrF2N2O4/c1-13-8-19(31-12-15-4-5-16(24)9-18(15)25)21(23)22(30)27(13)17-6-2-14(3-7-17)10-26-20(29)11-28/h2-9,28H,10-12H2,1H3,(H,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347934 (CHEMBL1802638) Show SMILES CNC(=O)c1ccc(OC)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(2.35,-36.25,;2.32,-34.71,;3.63,-33.91,;4.98,-34.65,;3.6,-32.37,;4.94,-31.6,;4.93,-30.05,;3.59,-29.29,;3.59,-27.75,;4.91,-26.97,;2.28,-30.06,;2.27,-31.6,;.94,-29.29,;.93,-27.74,;2.27,-26.97,;-.4,-26.98,;-1.73,-27.75,;-3.06,-26.98,;-4.4,-27.75,;-5.73,-26.98,;-7.05,-27.75,;-8.39,-26.99,;-8.39,-25.44,;-9.73,-24.67,;-7.06,-24.67,;-5.72,-25.44,;-4.39,-24.67,;-1.73,-29.3,;-3.07,-30.06,;-.4,-30.07,;-.4,-31.61,)| Show InChI InChI=1S/C22H19BrF2N2O4/c1-12-8-19(31-11-14-4-6-15(24)10-16(14)25)20(23)22(29)27(12)17-9-13(21(28)26-2)5-7-18(17)30-3/h4-10H,11H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay				Bioorg Med Chem Lett 21: 4066-71 (2011) Article DOI: 10.1016/j.bmcl.2011.04.121 BindingDB Entry DOI: 10.7270/Q2SB46R2
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM175242 (US11844801, Compound (M)-I | US9115089, 49) Show SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ncc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(3.33,-1.54,;2,-2.31,;2,-3.85,;.67,-4.62,;-.67,-3.85,;-.67,-2.31,;.67,-1.54,;.67,,;2,.77,;3.33,,;2,2.31,;.67,3.08,;.67,4.62,;2,5.39,;3.33,4.62,;3.33,3.08,;4.67,2.31,;6,3.08,;7.34,2.31,;6,4.62,;4.67,5.39,;4.67,6.93,;-.67,2.31,;-2,3.08,;-.67,.77,;-2,,;-2,-4.62,;-2,-6.16,;-3.33,-6.93,;-4.67,-6.16,;-4.67,-4.62,;-3.33,-3.85,;-6,-3.85,;-6.77,-2.52,;-5.23,-2.52,;-7.34,-4.62,)| Show InChI InChI=1S/C25H22ClF2N5O3/c1-13-10-30-18(17-5-6-29-24(32-17)25(3,4)35)9-20(13)33-14(2)7-21(22(26)23(33)34)36-12-19-16(28)8-15(27)11-31-19/h5-11,35H,12H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	n/a
CONFLUENCE LIFE SCIENCES, INC. US Patent					Assay Description The ability of compounds to inhibit activated phospho-p38alpha is evaluated using a p38alpha /MK2 and a p38alpha /PRAK cascade assay format. The kina...				US Patent US9115089 (2015) BindingDB Entry DOI: 10.7270/Q25M64H1
					More data for this Ligand-Target Pair

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