Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50347103 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_752994 (CHEMBL1798818) | ||
| IC50 | 8±n/a nM | ||
| Citation |  Selness, SR; Boehm, TL; Walker, JK; Devadas, B; Durley, RC; Kurumbail, R; Shieh, H; Xing, L; Hepperle, M; Rucker, PV; Jerome, KD; Benson, AG; Marrufo, LD; Madsen, HM; Hitchcock, J; Owen, TJ; Christie, L; Promo, MA; Hickory, BS; Alvira, E; Naing, W; Blevis-Bal, R; Devraj, RV; Messing, D; Schindler, JF; Hirsch, J; Saabye, M; Bonar, S; Webb, E; Anderson, G; Monahan, JB Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. Bioorg Med Chem Lett21:4059-65 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
| ||
| BDBM50347103 | |||
| n/a | |||
| Name | BDBM50347103 | ||
| Synonyms: | CHEMBL1797206 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17BrF4N2O2 | ||
| Mol. Mass. | 485.269 | ||
| SMILES | CN(C)c1cc(F)c(c(F)c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(6.77,-50.31,;6.78,-48.77,;8.1,-47.99,;5.44,-48,;5.44,-46.45,;4.11,-45.69,;4.11,-44.15,;2.79,-46.46,;2.78,-48,;1.44,-48.76,;4.11,-48.77,;1.45,-45.69,;1.45,-44.15,;2.79,-43.38,;.12,-43.37,;-1.21,-44.15,;-2.54,-43.38,;-3.87,-44.15,;-5.21,-43.39,;-6.53,-44.17,;-7.86,-43.41,;-7.87,-41.86,;-9.21,-41.09,;-6.54,-41.08,;-5.21,-41.85,;-3.87,-41.08,;-1.21,-45.69,;-2.54,-46.46,;.12,-46.45,;.12,-47.99,)| | ||
| Structure | 
| ||