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TargetMitogen-activated protein kinase 14
LigandBDBM19440
Substrate/CompetitorEGF receptor peptide
Meas. Tech.p38 Enzyme Assay.
pH7.5±n/a
Temperature303.15±n/a K
IC50 12±n/a nM
CommentsLPS-induced TNF production in rat (rLPS), inhibition @ 20 mpk =96 %.
Citation Graneto, MJ; Kurumbail, RG; Vazquez, ML; Shieh, HS; Pawlitz, JL; Williams, JM; Stallings, WC; Geng, L; Naraian, AS; Koszyk, FJ; Stealey, MA; Xu, XD; Weier, RM; Hanson, GJ; Mourey, RJ; Compton, RP; Mnich, SJ; Anderson, GD; Monahan, JB; Devraj, R Synthesis, Crystal Structure, and Activity of Pyrazole-Based Inhibitors of p38 Kinase. J Med Chem50:5712-9 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM19440
EGF receptor peptide
Name:EGF receptor peptide
Synonyms:Epidermal Growth Factor Receptor Peptide (EGFRP)
Type:Peptide
Mol. Mass.:2318.63
Organism:n/a
Description:n/a
Residue:21
Sequence:
KRELVEPLTPSGEAPNQALLR