Ki Summary

Reaction Details

Report a problem with these data

Target

Mitogen-activated protein kinase 14

Ligand

BDBM50347937

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_756761 (CHEMBL1805307)

IC50

4±n/a nM

Citation

Selness, SR; Devraj, RV; Devadas, B; Walker, JK; Boehm, TL; Durley, RC; Shieh, H; Xing, L; Rucker, PV; Jerome, KD; Benson, AG; Marrufo, LD; Madsen, HM; Hitchcock, J; Owen, TJ; Christie, L; Promo, MA; Hickory, BS; Alvira, E; Naing, W; Blevis-Bal, R; Messing, D; Yang, J; Mao, MK; Yalamanchili, G; Vonder Embse, R; Hirsch, J; Saabye, M; Bonar, S; Webb, E; Anderson, G; Monahan, JB Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett21:4066-71 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 14

Name:

Mitogen-activated protein kinase 14

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

41286.76

Organism:

Homo sapiens (Human)

Description:

Q16539

Residue:

360

Sequence:

MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES

BDBM50347937

n/a

Name

BDBM50347937

Synonyms:

CHEMBL1802641

Type

Small organic molecule

Emp. Form.

C22H19BrF2N2O4

Mol. Mass.

493.298

SMILES

CNC(=O)c1ccc(C)c(c1)-n1c(CO)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(2.58,-49.12,;2.54,-47.58,;3.86,-46.78,;5.21,-47.52,;3.83,-45.24,;5.16,-44.47,;5.15,-42.92,;3.82,-42.16,;3.81,-40.62,;2.5,-42.93,;2.49,-44.48,;1.17,-42.17,;1.16,-40.62,;2.49,-39.84,;2.49,-38.3,;-.17,-39.85,;-1.5,-40.62,;-2.84,-39.85,;-4.17,-40.62,;-5.5,-39.85,;-6.83,-40.62,;-8.16,-39.86,;-8.17,-38.31,;-9.5,-37.55,;-6.83,-37.54,;-5.5,-38.31,;-4.16,-37.55,;-1.51,-42.17,;-2.84,-42.94,;-.17,-42.94,;-.17,-44.48,)|

Structure