| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vasopressin V1b receptor |
|---|
| Ligand | BDBM50325847 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_652647 (CHEMBL1225850) |
|---|
| IC50 | 120±n/a nM |
|---|
| Citation |  Letourneau, JJ; Riviello, CM; Li, H; Cole, AG; Ho, KK; Zanetakos, HA; Desai, H; Zhao, J; Auld, DS; Napier, SE; Thomson, FJ; Goan, KA; Morphy, JR; Ohlmeyer, MH; Webb, ML Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists. Bioorg Med Chem Lett20:5394-7 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vasopressin V1b receptor |
|---|
| Name: | Vasopressin V1b receptor |
|---|
| Synonyms: | AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46985.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P47901 |
|---|
| Residue: | 424 |
|---|
| Sequence: | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLG
QLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQG
SGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVG
GGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSV
QMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQ
PRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAE
TIIF
|
|
|
|---|
| BDBM50325847 |
|---|
| n/a |
|---|
| Name | BDBM50325847 |
|---|
| Synonyms: | CHEMBL1223814 | N-(cyclopropylmethyl)-2-(6-(3-morpholinopropoxy)-4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H32N4O4 |
|---|
| Mol. Mass. | 476.5674 |
|---|
| SMILES | O=C(Cn1c(nc2ccc(OCCCN3CCOCC3)cc2c1=O)-c1ccccc1)NCC1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
