| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 1 |
|---|
| Ligand | BDBM50331098 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_686239 (CHEMBL1292995) |
|---|
| IC50 | 4100±n/a nM |
|---|
| Citation |  Mitsuhashi, S; Takenaka, J; Iwamori, K; Nakajima, N; Ubukata, M Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives. Bioorg Med Chem18:8106-11 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inosine-5'-monophosphate dehydrogenase 1 |
|---|
| Name: | Inosine-5'-monophosphate dehydrogenase 1 |
|---|
| Synonyms: | IMDH1_HUMAN | IMP dehydrogenase 1 | IMPD 1 | IMPD1 | IMPDH-I | IMPDH1 | Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55407.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant IMPDH1 expressed in E. coli. |
|---|
| Residue: | 514 |
|---|
| Sequence: | MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT
PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS
QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
|
|
|
|---|
| BDBM50331098 |
|---|
| n/a |
|---|
| Name | BDBM50331098 |
|---|
| Synonyms: | 6-(4-acetoxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid | CHEMBL238403 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22O7 |
|---|
| Mol. Mass. | 362.3738 |
|---|
| SMILES | COc1c(C)c2COC(=O)c2c(OC(C)=O)c1C\C=C(/C)CCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
