| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
|---|
| Ligand | BDBM50340014 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_740122 (CHEMBL1763182) |
|---|
| IC50 | 1200±n/a nM |
|---|
| Citation |  Li, AR; Zhang, J; Greenberg, J; Lee, T; Liu, J Discovery of non-glucoside SGLT2 inhibitors. Bioorg Med Chem Lett21:2472-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/glucose cotransporter 2 |
|---|
| Name: | Sodium/glucose cotransporter 2 |
|---|
| Synonyms: | Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 2 | SC5A2_MOUSE | Sglt2 | Slc5a2 | Sodium/glucose cotransporter 2 | Solute carrier family 5 member 2 | sodium-dependent glucose cotransporter 2 (SGLT2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 73014.31 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | Q923I7 |
|---|
| Residue: | 670 |
|---|
| Sequence: | MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTV
SKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKEL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTL
GISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQS
PAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMT
VAVFLWGFYA
|
|
|
|---|
| BDBM50340014 |
|---|
| n/a |
|---|
| Name | BDBM50340014 |
|---|
| Synonyms: | 4-((5-(4-chlorobenzylthio)-4-methyl-4H-1,2,4-triazol-3-yl)methyl)-6-(trifluoromethyl)-2H-benzo[b][1,4]thiazin-3(4H)-one | CHEMBL1762483 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16ClF3N4OS2 |
|---|
| Mol. Mass. | 484.945 |
|---|
| SMILES | Cn1c(CN2C(=O)CSc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
