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Compile Data Set for Download or QSAR

Found 185 hits with Last Name = 'greenberg' and Initial = 'j'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344680
PNG
(4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-1,2,4-tri...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1-c1ccc(Cl)cn1
Show InChI InChI=1S/C21H22ClN5O2/c1-4-7-26-18(24-25-21(26)16-6-5-15(22)10-23-16)11-27-17-9-13(2)8-14(3)20(17)29-12-19(27)28/h5-6,8-10H,4,7,11-12H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344669
PNG
(6,8-dichloro-4-((5-(5-chloropyridin-2-yl)-4-(3,3,3...)
Show SMILES FC(F)(F)CCn1c(CN2C(=O)COc3c(Cl)cc(Cl)cc23)nnc1-c1ccc(Cl)cn1
Show InChI InChI=1S/C19H13Cl3F3N5O2/c20-10-1-2-13(26-7-10)18-28-27-15(29(18)4-3-19(23,24)25)8-30-14-6-11(21)5-12(22)17(14)32-9-16(30)31/h1-2,5-7H,3-4,8-9H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 2


(Rattus norvegicus)		BDBM50344685
PNG
(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1C1Cc2ccccc2C1
Show InChI InChI=1S/C25H28N4O2/c1-4-9-28-22(26-27-25(28)20-12-18-7-5-6-8-19(18)13-20)14-29-21-11-16(2)10-17(3)24(21)31-15-23(29)30/h5-8,10-11,20H,4,9,12-15H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT2

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Rattus norvegicus)		BDBM50344681
PNG
(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1-c1ccccn1
Show InChI InChI=1S/C21H23N5O2/c1-4-9-25-18(23-24-21(25)16-7-5-6-8-22-16)12-26-17-11-14(2)10-15(3)20(17)28-13-19(26)27/h5-8,10-11H,4,9,12-13H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat SGLT2

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344679
PNG
(4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-1,2,4-tri...)
Show SMILES CCCn1c(CN2C(=O)COc3c2cc(C)cc3[N+]([O-])=O)nnc1-c1ccc(Cl)cn1
Show InChI InChI=1S/C20H19ClN6O4/c1-3-6-25-17(23-24-20(25)14-5-4-13(21)9-22-14)10-26-15-7-12(2)8-16(27(29)30)19(15)31-11-18(26)28/h4-5,7-9H,3,6,10-11H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344685
PNG
(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1C1Cc2ccccc2C1
Show InChI InChI=1S/C25H28N4O2/c1-4-9-28-22(26-27-25(28)20-12-18-7-5-6-8-19(18)13-20)14-29-21-11-16(2)10-17(3)24(21)31-15-23(29)30/h5-8,10-11,20H,4,9,12-15H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344678
PNG
(6-chloro-4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-...)
Show SMILES CCCn1c(CN2C(=O)COc3c2cc(Cl)cc3[N+]([O-])=O)nnc1-c1ccc(Cl)cn1
Show InChI InChI=1S/C19H16Cl2N6O4/c1-2-5-25-16(23-24-19(25)13-4-3-11(20)8-22-13)9-26-14-6-12(21)7-15(27(29)30)18(14)31-10-17(26)28/h3-4,6-8H,2,5,9-10H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344675
PNG
(6-chloro-4-((5-(5-chloropyridin-2-yl)-4-(3,3,3-tri...)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2N(Cc3nnc(-c4ccc(Cl)cn4)n3CCC(F)(F)F)C(=O)COc12
Show InChI InChI=1S/C19H13Cl2F3N6O4/c20-10-1-2-12(25-7-10)18-27-26-15(28(18)4-3-19(22,23)24)8-29-13-5-11(21)6-14(30(32)33)17(13)34-9-16(29)31/h1-2,5-7H,3-4,8-9H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344676
PNG
(6-chloro-8-nitro-4-((5-(5-(trifluoromethyl)pyridin...)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2N(Cc3nnc(-c4ccc(cn4)C(F)(F)F)n3CCC(F)(F)F)C(=O)COc12
Show InChI InChI=1S/C20H13ClF6N6O4/c21-11-5-13-17(14(6-11)33(35)36)37-9-16(34)32(13)8-15-29-30-18(31(15)4-3-19(22,23)24)12-2-1-10(7-28-12)20(25,26)27/h1-2,5-7H,3-4,8-9H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344666
PNG
(4-((5-(benzyloxymethyl)-4-(3,3,3-trifluoropropyl)-...)
Show SMILES FC(F)(F)CCn1c(COCc2ccccc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H19Cl2F3N4O3/c23-15-8-16(24)21-17(9-15)31(20(32)13-34-21)10-18-28-29-19(30(18)7-6-22(25,26)27)12-33-11-14-4-2-1-3-5-14/h1-5,8-9H,6-7,10-13H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344683
PNG
(6,8-dimethyl-4-((5-((1R,2R)-2-phenylcyclopropyl)-4...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C25H28N4O2/c1-4-10-28-22(26-27-25(28)20-13-19(20)18-8-6-5-7-9-18)14-29-21-12-16(2)11-17(3)24(21)31-15-23(29)30/h5-9,11-12,19-20H,4,10,13-15H2,1-3H3/t19-,20+/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344684
PNG
((R)-6,8-dimethyl-4-((4-propyl-5-(1,2,3,4-tetrahydr...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1[C@@H]1CCc2ccccc2C1 |r|
Show InChI InChI=1S/C26H30N4O2/c1-4-11-29-23(15-30-22-13-17(2)12-18(3)25(22)32-16-24(30)31)27-28-26(29)21-10-9-19-7-5-6-8-20(19)14-21/h5-8,12-13,21H,4,9-11,14-16H2,1-3H3/t21-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344670
PNG
(6,8-dichloro-4-((5-(2-methylthiazol-4-yl)-4-(3,3,3...)
Show SMILES Cc1nc(cs1)-c1nnc(CN2C(=O)COc3c(Cl)cc(Cl)cc23)n1CCC(F)(F)F
Show InChI InChI=1S/C18H14Cl2F3N5O2S/c1-9-24-12(8-31-9)17-26-25-14(27(17)3-2-18(21,22)23)6-28-13-5-10(19)4-11(20)16(13)30-7-15(28)29/h4-5,8H,2-3,6-7H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344681
PNG
(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1-c1ccccn1
Show InChI InChI=1S/C21H23N5O2/c1-4-9-25-18(23-24-21(25)16-7-5-6-8-22-16)12-26-17-11-14(2)10-15(3)20(17)28-13-19(26)27/h5-8,10-11H,4,9,12-13H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344671
PNG
(CHEMBL1779219 | rac-6,8-dichloro-4-((5-(2-phenylcy...)
Show SMILES FC(F)(F)CCn1c(CN2C(=O)COc3c(Cl)cc(Cl)cc23)nnc1C1CC1c1ccccc1
Show InChI InChI=1S/C23H19Cl2F3N4O2/c24-14-8-17(25)21-18(9-14)32(20(33)12-34-21)11-19-29-30-22(31(19)7-6-23(26,27)28)16-10-15(16)13-4-2-1-3-5-13/h1-5,8-9,15-16H,6-7,10-12H2
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344668
PNG
(6,8-dichloro-4-((5-(pyridin-2-yl)-4-(3,3,3-trifluo...)
Show SMILES FC(F)(F)CCn1c(CN2C(=O)COc3c(Cl)cc(Cl)cc23)nnc1-c1ccccn1
Show InChI InChI=1S/C19H14Cl2F3N5O2/c20-11-7-12(21)17-14(8-11)29(16(30)10-31-17)9-15-26-27-18(13-3-1-2-5-25-13)28(15)6-4-19(22,23)24/h1-3,5,7-8H,4,6,9-10H2
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344673
PNG
(6,8-dichloro-4-((5-(2,3-dihydro-1H-inden-2-yl)-4-(...)
Show SMILES FC(F)(F)CCn1c(CN2C(=O)COc3c(Cl)cc(Cl)cc23)nnc1C1Cc2ccccc2C1
Show InChI InChI=1S/C23H19Cl2F3N4O2/c24-16-9-17(25)21-18(10-16)32(20(33)12-34-21)11-19-29-30-22(31(19)6-5-23(26,27)28)15-7-13-3-1-2-4-14(13)8-15/h1-4,9-10,15H,5-8,11-12H2
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344672
PNG
(CHEMBL1779220 | rac-6,8-dichloro-4-((5-(1,2,3,4-te...)
Show SMILES FC(F)(F)CCn1c(CN2C(=O)COc3c(Cl)cc(Cl)cc23)nnc1C1CCc2ccccc2C1
Show InChI InChI=1S/C24H21Cl2F3N4O2/c25-17-10-18(26)22-19(11-17)33(21(34)13-35-22)12-20-30-31-23(32(20)8-7-24(27,28)29)16-6-5-14-3-1-2-4-15(14)9-16/h1-4,10-11,16H,5-9,12-13H2
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n/an/a 14n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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n/an/a 16n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]dapagliflozin from human SGLT2 expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340013
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]dapagliflozin from human SGLT2 expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344690
PNG
(CHEMBL1779207 | N-(6-chloro-4-((5-(4-chloropheneth...)
Show SMILES CS(=O)(=O)N(c1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12)S(C)(=O)=O
Show InChI InChI=1S/C24H24Cl2F3N5O6S2/c1-41(36,37)34(42(2,38)39)19-12-17(26)11-18-23(19)40-14-22(35)33(18)13-21-31-30-20(32(21)10-9-24(27,28)29)8-5-15-3-6-16(25)7-4-15/h3-4,6-7,11-12H,5,8-10,13-14H2,1-2H3
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n/an/a 21n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344691
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12
Show InChI InChI=1S/C22H18Cl2F3N5O4/c23-14-4-1-13(2-5-14)3-6-18-28-29-19(30(18)8-7-22(25,26)27)11-31-16-9-15(24)10-17(32(34)35)21(16)36-12-20(31)33/h1-2,4-5,9-10H,3,6-8,11-12H2
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344667
PNG
(6,8-dichloro-4-((5-(4-chlorophenyl)-4-(3,3,3-trifl...)
Show SMILES FC(F)(F)CCn1c(CN2C(=O)COc3c(Cl)cc(Cl)cc23)nnc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H14Cl3F3N4O2/c21-12-3-1-11(2-4-12)19-28-27-16(29(19)6-5-20(24,25)26)9-30-15-8-13(22)7-14(23)18(15)32-10-17(30)31/h1-4,7-8H,5-6,9-10H2
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n/an/a 23n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340007
PNG
(4-((4-butyl-5-(4-chlorophenethyl)-4H-1,2,4-triazol...)
Show SMILES CCCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C23H24Cl2N4O2/c1-2-3-12-28-21(11-6-16-4-7-17(24)8-5-16)26-27-22(28)14-29-19-13-18(25)9-10-20(19)31-15-23(29)30/h4-5,7-10,13H,2-3,6,11-12,14-15H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340008
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-(cyclopropylm...)
Show SMILES Clc1ccc(CCc2nnc(CN3C(=O)COc4ccc(Cl)cc34)n2CC2CC2)cc1
Show InChI InChI=1S/C23H22Cl2N4O2/c24-17-6-3-15(4-7-17)5-10-21-26-27-22(29(21)12-16-1-2-16)13-28-19-11-18(25)8-9-20(19)31-14-23(28)30/h3-4,6-9,11,16H,1-2,5,10,12-14H2
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n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344688
PNG
(8-amino-6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,...)
Show SMILES Nc1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12
Show InChI InChI=1S/C22H20Cl2F3N5O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(25,26)27)11-32-17-10-15(24)9-16(28)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12,28H2
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n/an/a 36n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/a 36n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGLT2

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340029
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-propyl-4H-1,2...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C22H22Cl2N4O2/c1-2-11-27-20(10-5-15-3-6-16(23)7-4-15)25-26-21(27)13-28-18-12-17(24)8-9-19(18)30-14-22(28)29/h3-4,6-9,12H,2,5,10-11,13-14H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340012
PNG
(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-propyl-4H...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H21Cl3N4O2/c1-2-9-28-19(8-5-14-3-6-15(23)7-4-14)26-27-20(28)12-29-18-11-16(24)10-17(25)22(18)31-13-21(29)30/h3-4,6-7,10-11H,2,5,8-9,12-13H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344674
PNG
(6-chloro-8-nitro-4-((5-(pyridin-2-yl)-4-(3,3,3-tri...)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2N(Cc3nnc(-c4ccccn4)n3CCC(F)(F)F)C(=O)COc12
Show InChI InChI=1S/C19H14ClF3N6O4/c20-11-7-13-17(14(8-11)29(31)32)33-10-16(30)28(13)9-15-25-26-18(12-3-1-2-5-24-12)27(15)6-4-19(21,22)23/h1-3,5,7-8H,4,6,9-10H2
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n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344686
PNG
(CHEMBL1779203 | methyl 6-chloro-4-((5-(4-chlorophe...)
Show SMILES COC(=O)c1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12
Show InChI InChI=1S/C24H21Cl2F3N4O4/c1-36-23(35)17-10-16(26)11-18-22(17)37-13-21(34)33(18)12-20-31-30-19(32(20)9-8-24(27,28)29)7-4-14-2-5-15(25)6-3-14/h2-3,5-6,10-11H,4,7-9,12-13H2,1H3
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n/an/a 57n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344692
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(cc(Cl)cc12)C#N
Show InChI InChI=1S/C23H18Cl2F3N5O2/c24-16-4-1-14(2-5-16)3-6-19-30-31-20(32(19)8-7-23(26,27)28)12-33-18-10-17(25)9-15(11-29)22(18)35-13-21(33)34/h1-2,4-5,9-10H,3,6-8,12-13H2
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n/an/a 59n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340010
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Show SMILES FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C22H19Cl2F3N4O2/c23-15-4-1-14(2-5-15)3-8-19-28-29-20(30(19)10-9-22(25,26)27)12-31-17-11-16(24)6-7-18(17)33-13-21(31)32/h1-2,4-7,11H,3,8-10,12-13H2
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344665
PNG
(6,8-dichloro-4-((5-((4-chlorophenoxy)methyl)-4-(3,...)
Show SMILES FC(F)(F)CCn1c(COc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C21H16Cl3F3N4O3/c22-12-1-3-14(4-2-12)33-10-18-29-28-17(30(18)6-5-21(25,26)27)9-31-16-8-13(23)7-15(24)20(16)34-11-19(31)32/h1-4,7-8H,5-6,9-11H2
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n/an/a 73n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340023
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(C)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O2S/c1-3-25-19(23-24-21(25)29-13-15-5-7-16(22)8-6-15)11-26-17-10-14(2)4-9-18(17)28-12-20(26)27/h4-10H,3,11-13H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344694
PNG
(CHEMBL1779211 | rac-6,8-dichloro-4-((5-(2-phenylpr...)
Show SMILES CC(Cc1nnc(CN2C(=O)COc3c(Cl)cc(Cl)cc23)n1CCC(F)(F)F)c1ccccc1
Show InChI InChI=1S/C23H21Cl2F3N4O2/c1-14(15-5-3-2-4-6-15)9-19-29-30-20(31(19)8-7-23(26,27)28)12-32-18-11-16(24)10-17(25)22(18)34-13-21(32)33/h2-6,10-11,14H,7-9,12-13H2,1H3
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n/an/a 89n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340021
PNG
(6-bromo-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(Br)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18BrClN4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-6-15(22)7-4-13)10-26-16-9-14(21)5-8-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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n/an/a 90n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344677
PNG
(6-chloro-3-oxo-4-((5-(pyridin-2-yl)-4-(3,3,3-trifl...)
Show SMILES FC(F)(F)CCn1c(CN2C(=O)COc3c(cc(Cl)cc23)C#N)nnc1-c1ccccn1
Show InChI InChI=1S/C20H14ClF3N6O2/c21-13-7-12(9-25)18-15(8-13)30(17(31)11-32-18)10-16-27-28-19(14-3-1-2-5-26-14)29(16)6-4-20(22,23)24/h1-3,5,7-8H,4,6,10-11H2
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n/an/a 110n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340022
PNG
(6-chloro-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(Cl)cc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2S/c1-2-25-18(23-24-20(25)29-12-13-3-5-14(21)6-4-13)10-26-16-9-15(22)7-8-17(16)28-11-19(26)27/h3-9H,2,10-12H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340026
PNG
(8-chloro-4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2...)
Show SMILES CCn1c(CN2C(=O)COc3c(Cl)cccc23)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2S/c1-2-25-17(23-24-20(25)29-12-13-6-8-14(21)9-7-13)10-26-16-5-3-4-15(22)19(16)28-11-18(26)27/h3-9H,2,10-12H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340009
PNG
(6-chloro-4-((5-(4-chlorophenethyl)-4-isobutyl-4H-1...)
Show SMILES CC(C)Cn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(Cl)cc12
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15(2)12-29-21(10-5-16-3-6-17(24)7-4-16)26-27-22(29)13-28-19-11-18(25)8-9-20(19)31-14-23(28)30/h3-4,6-9,11,15H,5,10,12-14H2,1-2H3
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n/an/a 160n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340028
PNG
(4-((5-(4-chlorophenethyl)-4-propyl-4H-1,2,4-triazo...)
Show SMILES CCCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C23H22ClF3N4O2/c1-2-11-30-20(10-5-15-3-7-17(24)8-4-15)28-29-21(30)13-31-18-12-16(23(25,26)27)6-9-19(18)33-14-22(31)32/h3-4,6-9,12H,2,5,10-11,13-14H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50340019
PNG
(4-((5-(4-chlorobenzylthio)-4-ethyl-4H-1,2,4-triazo...)
Show SMILES CCn1c(CN2C(=O)COc3ccc(cc23)C(F)(F)F)nnc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClF3N4O2S/c1-2-28-18(26-27-20(28)32-12-13-3-6-15(22)7-4-13)10-29-16-9-14(21(23,24)25)5-8-17(16)31-11-19(29)30/h3-9H,2,10-12H2,1H3
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n/an/a 250n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...

Bioorg Med Chem Lett 21: 2472-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.056
BindingDB Entry DOI: 10.7270/Q25Q4WD2
More data for this
Ligand-Target Pair
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