| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
|---|
| Ligand | BDBM50344679 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_749005 (CHEMBL1781790) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Du, X; Lizarzaburu, M; Turcotte, S; Lee, T; Greenberg, J; Shan, B; Fan, P; Ling, Y; Medina, JC; Houze, J Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors. Bioorg Med Chem Lett21:3774-9 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/glucose cotransporter 2 |
|---|
| Name: | Sodium/glucose cotransporter 2 |
|---|
| Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 72902.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31639 |
|---|
| Residue: | 672 |
|---|
| Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
|
|
|
|---|
| BDBM50344679 |
|---|
| n/a |
|---|
| Name | BDBM50344679 |
|---|
| Synonyms: | 4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-1,2,4-triazol-3-yl)methyl)-6-methyl-8-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one | CHEMBL1779339 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19ClN6O4 |
|---|
| Mol. Mass. | 442.856 |
|---|
| SMILES | CCCn1c(CN2C(=O)COc3c2cc(C)cc3[N+]([O-])=O)nnc1-c1ccc(Cl)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
