| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
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| Ligand | BDBM50344681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_749012 (CHEMBL1781797) |
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| IC50 | 3.5±n/a nM |
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| Citation |  Du, X; Lizarzaburu, M; Turcotte, S; Lee, T; Greenberg, J; Shan, B; Fan, P; Ling, Y; Medina, JC; Houze, J Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors. Bioorg Med Chem Lett21:3774-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/glucose cotransporter 2 |
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| Name: | Sodium/glucose cotransporter 2 |
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| Synonyms: | SC5A2_RAT | Sglt2 | Slc5a2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72969.23 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_938467 |
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| Residue: | 670 |
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| Sequence: | MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTV
SKDPAVGNISSTCYQPRPDSYHLLRDPVTGGLPWPALLLGLTIVSGWHWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDREL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTL
AISRCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQS
PAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMT
VAVFLWGFYA
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| BDBM50344681 |
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| n/a |
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| Name | BDBM50344681 |
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| Synonyms: | 6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | CHEMBL1779341 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N5O2 |
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| Mol. Mass. | 377.4396 |
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| SMILES | CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1-c1ccccn1 |
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| Structure | 
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