Reaction Details |
| Report a problem with these data |
Target | Sodium/glucose cotransporter 2 |
---|
Ligand | BDBM50344677 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_749005 (CHEMBL1781790) |
---|
IC50 | 110±n/a nM |
---|
Citation | Du, X; Lizarzaburu, M; Turcotte, S; Lee, T; Greenberg, J; Shan, B; Fan, P; Ling, Y; Medina, JC; Houze, J Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors. Bioorg Med Chem Lett21:3774-9 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium/glucose cotransporter 2 |
---|
Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
Type: | Protein |
Mol. Mass.: | 72902.00 |
Organism: | Homo sapiens (Human) |
Description: | P31639 |
Residue: | 672 |
Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
|
|
|
BDBM50344677 |
---|
n/a |
---|
Name | BDBM50344677 |
Synonyms: | 6-chloro-3-oxo-4-((5-(pyridin-2-yl)-4-(3,3,3-trifluoropropyl)-4H-1,2,4-triazol-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carbonitrile | CHEMBL1779337 |
Type | Small organic molecule |
Emp. Form. | C20H14ClF3N6O2 |
Mol. Mass. | 462.812 |
SMILES | FC(F)(F)CCn1c(CN2C(=O)COc3c(cc(Cl)cc23)C#N)nnc1-c1ccccn1 |
Structure |
|