| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
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| Ligand | BDBM50343915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_747537 (CHEMBL1777071) |
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| IC50 | 990±n/a nM |
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| Citation |  Chen, Z; Wu, Y; Liu, Y; Yang, S; Chen, Y; Lai, L Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase. J Med Chem54:3650-60 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukotriene A-4 hydrolase |
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| Name: | Leukotriene A-4 hydrolase |
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| Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
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| Type: | Hydrolase; metalloprotease |
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| Mol. Mass.: | 69280.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant LTA4H. |
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| Residue: | 611 |
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| Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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| BDBM50343915 |
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| n/a |
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| Name | BDBM50343915 |
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| Synonyms: | 1-(2-(4-(4-Fluorophenoxy)phenoxy)ethyl)pyrrolidine | CHEMBL1775102 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20FNO2 |
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| Mol. Mass. | 301.3553 |
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| SMILES | Fc1ccc(Oc2ccc(OCCN3CCCC3)cc2)cc1 |
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| Structure | 
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