| Reaction Details |
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 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Ligand | BDBM50347956 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_755938 (CHEMBL1803828) |
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| IC50 | 10±n/a nM |
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| Citation |  Wu, Y; Karna, S; Choi, CH; Tong, M; Tai, HH; Na, DH; Jang, CH; Cho, H Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors. J Med Chem54:5260-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28974.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15428 |
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| Residue: | 266 |
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| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
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| BDBM50347956 |
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| n/a |
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| Name | BDBM50347956 |
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| Synonyms: | CHEMBL1800143 | US8637558, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22ClNO3S |
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| Mol. Mass. | 379.901 |
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| SMILES | OC1=NC(=O)C(S1)=Cc1ccc(OCCCC2CCCCC2)c(Cl)c1 |w:7.8,t:1| |
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| Structure | 
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