| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50348992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_758706 (CHEMBL1810158) |
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| IC50 | 1.02±n/a nM |
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| Citation |  Wu, Y; Shi, C; Sun, X; Wu, X; Sun, H Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of renin. Bioorg Med Chem19:4238-49 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50348992 |
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| n/a |
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| Name | BDBM50348992 |
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| Synonyms: | CHEMBL1808236 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H59N3O6 |
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| Mol. Mass. | 641.8809 |
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| SMILES | COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)CNC(=O)c2ccccc2)C(C)C)ccc1OC |r| |
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| Structure | 
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