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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50351375 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_764455 (CHEMBL1821007) | ||
| IC50 | 37±n/a nM | ||
| Citation |  Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem19:5432-45 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50351375 | |||
| n/a | |||
| Name | BDBM50351375 | ||
| Synonyms: | CHEMBL1819065 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H28N4OS | ||
| Mol. Mass. | 396.549 | ||
| SMILES | CCC(CC)Nc1c2CSCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C |(31.02,-13.82,;29.68,-14.56,;29.65,-16.1,;30.97,-16.9,;32.31,-16.15,;28.3,-16.85,;28.27,-18.39,;26.92,-19.13,;25.46,-18.63,;24.53,-19.86,;25.41,-21.12,;26.89,-20.67,;28.21,-21.47,;29.57,-20.71,;31.02,-21.21,;31.94,-19.97,;33.48,-19.99,;31.05,-18.72,;29.59,-19.18,;31.48,-22.68,;30.44,-23.8,;30.9,-25.27,;32.4,-25.61,;32.86,-27.08,;31.82,-28.22,;33.44,-24.47,;32.98,-23.01,;34.02,-21.87,)| | ||
| Structure | 
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