| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50364410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_805401 (CHEMBL1955294) |
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| EC50 | 45±n/a nM |
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| Citation |  Reed, AB; Lanman, BA; Neira, S; Harrington, PE; Sham, KK; Frohn, M; Pickrell, AJ; Tasker, AS; Gore, A; Fiorino, M; Itano, A; McElvain, M; Middleton, S; Morrison, H; Xu, H; Xu, Y; Wong, M; Cee, VJ Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups. Bioorg Med Chem Lett22:1779-83 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50364410 |
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| n/a |
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| Name | BDBM50364410 |
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| Synonyms: | CHEMBL1950480 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15FN2S |
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| Mol. Mass. | 346.421 |
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| SMILES | Fc1ccccc1-c1nc2ccc(nc2s1)C1(CC1)c1ccccc1 |
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| Structure | 
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