Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50027088 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_148541 |
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EC50 | 500±n/a nM |
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Citation | Burke, TR; Bajwa, BS; Jacobson, AE; Rice, KC; Streaty, RA; Klee, WA Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors. J Med Chem27:1570-4 (1985) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50027088 |
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n/a |
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Name | BDBM50027088 |
Synonyms: | CHEMBL291099 | N-(1-{2-[4-(2-Bromo-acetylamino)-phenyl]-ethyl}-piperidin-4-yl)-N-phenyl-propionamide |
Type | Small organic molecule |
Emp. Form. | C24H30BrN3O2 |
Mol. Mass. | 472.418 |
SMILES | CCC(=O)N(C1CCN(CCc2ccc(NC(=O)CBr)cc2)CC1)c1ccccc1 |
Structure |
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