| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Ligand | BDBM50044887 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_213114 (CHEMBL873905) |
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| IC50 | 3600±n/a nM |
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| Citation |  Jones, CD; Audia, JE; Lawhorn, DE; McQuaid, LA; Neubauer, BL; Pike, AJ; Pennington, PA; Stamm, NB; Toomey, RE; Hirsch, KS Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase. J Med Chem36:421-3 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29472.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18405 |
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| Residue: | 259 |
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| Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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| BDBM50044887 |
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| n/a |
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| Name | BDBM50044887 |
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| Synonyms: | 8-Chloro-10b-methyl-1,4,6,10b-tetrahydro-2H-benzo[f]quinolin-3-one | CHEMBL134819 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14ClNO |
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| Mol. Mass. | 247.72 |
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| SMILES | CC12CCC(=O)NC1=CCc1cc(Cl)ccc21 |c:8| |
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| Structure | 
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