Ki Summary

Reaction Details

Report a problem with these data

Target

Cholecystokinin receptor type A

Ligand

BDBM50062009

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_50191 (CHEMBL663484)

IC50

10804±n/a nM

Citation

Trivedi, BK; Padia, JK; Holmes, A; Rose, S; Wright, DS; Hinton, JP; Pritchard, MC; Eden, JM; Kneen, C; Webdale, L; Suman-Chauhan, N; Boden, P; Singh, L; Field, MJ; Hill, D Second generation"peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem41:38-45 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cholecystokinin receptor type A

Name:

Cholecystokinin receptor type A

Synonyms:

CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49676.37

Organism:

RAT

Description:

Cholecystokinin central 0 RAT::P30551

Residue:

444

Sequence:

MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQI
LLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK
DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAAT
WCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVM
VVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQL
SSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAE
KHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEE
DGRTIRALLSRYSYSHMSTSAPPP

BDBM50062009

n/a

Name

BDBM50062009

Synonyms:

CHEMBL142063 | [(R)-2-(1H-Indol-3-yl)-1-methyl-1-(pyrrolidin-1-ylcarbamoyl)-ethyl]-carbamic acid adamantan-2-yl ester

Type

Small organic molecule

Emp. Form.

C27H36N4O3

Mol. Mass.

464.5997

SMILES

C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 |wU:1.13,wD:1.0,TLB:18:19:16.17.22:23,15:16:23:19.25.20,THB:18:17:23:19.25.20,20:21:16:19.18.25,20:19:16:21.22.23,(2.25,-7.79,;2.25,-9.15,;2.34,-10.7,;3.7,-11.4,;2.46,-12.31,;2.93,-13.79,;4.48,-13.78,;5.51,-14.93,;7,-14.61,;7.49,-13.13,;6.46,-12,;4.97,-12.31,;.87,-8.64,;-.41,-9.5,;-.39,-10.96,;-1.8,-8.8,;-3.09,-9.66,;-4.48,-9.08,;-5.84,-9.57,;-5.83,-11.05,;-7.03,-12.33,;-5.52,-11.91,;-5.54,-10.32,;-4.12,-12.48,;-3.1,-11.19,;-4.51,-11.54,;3.54,-8.48,;3.52,-7.1,;4.78,-9.22,;6.07,-8.36,;6.14,-6.81,;7.63,-6.39,;8.48,-7.68,;7.52,-8.89,)|

Structure