| Reaction Details |
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 | Report a problem with these data |
| Target | Matrilysin |
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| Ligand | BDBM50291979 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105038 (CHEMBL711552) |
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| IC50 | 886±n/a nM |
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| Citation |  Pikul, S; McDow Dunham, KL; Almstead, NG; De, B; Natchus, MG; Anastasio, MV; McPhail, SJ; Snider, CE; Taiwo, YO; Chen, L; Dunaway, CM; Gu, F; Mieling, GE Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases. J Med Chem42:87-94 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrilysin |
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| Name: | Matrilysin |
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| Synonyms: | MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29681.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09237 |
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| Residue: | 267 |
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| Sequence: | MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD
PQNFKLSQDDIKGIQKLYGKRSNSRKK
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| BDBM50291979 |
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| n/a |
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| Name | BDBM50291979 |
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| Synonyms: | CHEMBL176602 | N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID | N-hydroxy-2(R)-[[(R)-methylphenylphosphinyl]-benzylamino]-4-methylpentanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H27N2O3P |
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| Mol. Mass. | 374.4137 |
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| SMILES | CC(C)C[C@@H](N(Cc1ccccc1)[P@](C)(=O)c1ccccc1)C(=O)NO |
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| Structure | 
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