Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Delta-type opioid receptor |
---|
Ligand | BDBM50105088 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_145324 (CHEMBL750412) |
---|
IC50 | 4120±n/a nM |
---|
Citation | Poulain, R; Horvath, D; Bonnet, B; Eckhoff, C; Chapelain, B; Bodinier, MC; Déprez, B From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. J Med Chem44:3378-90 (2001) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Delta-type opioid receptor |
---|
Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
|
|
|
BDBM50105088 |
---|
n/a |
---|
Name | BDBM50105088 |
Synonyms: | 1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-ylmethyl-1,3,8-triaza-spiro[4.5]decan-4-one | 8-Benzo[1,2,5]thiadiazol-5-ylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | CHEMBL325750 |
Type | Small organic molecule |
Emp. Form. | C20H21N5OS |
Mol. Mass. | 379.479 |
SMILES | O=C1NCN(c2ccccc2)C11CCN(Cc2ccc3nsnc3c2)CC1 |
Structure |
|