| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK3 |
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| Ligand | BDBM50201502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_446752 (CHEMBL897051) |
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| IC50 | 46±n/a nM |
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| Citation |  Clark, MP; George, KM; Bookland, RG; Chen, J; Laughlin, SK; Thakur, KD; Lee, W; Davis, JR; Cabrera, EJ; Brugel, TA; VanRens, JC; Laufersweiler, MJ; Maier, JA; Sabat, MP; Golebiowski, A; Easwaran, V; Webster, ME; De, B; Zhang, G Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3). Bioorg Med Chem Lett17:1250-3 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK3 |
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| Name: | Tyrosine-protein kinase JAK3 |
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| Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase |
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| Type: | Protein |
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| Mol. Mass.: | 125111.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52333 |
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| Residue: | 1124 |
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| Sequence: | MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKA
SGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGL
RKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQR
PGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIM
DLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNP
LGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPK
EKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR
HEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ
EFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFS
GVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
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| BDBM50201502 |
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| n/a |
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| Name | BDBM50201502 |
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| Synonyms: | 2-(3H-imidazo[4,5-c]pyridin-3-yl)-7-methyl-N-(3-morpholinopropyl)-4-((S)-1-phenylethylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | CHEMBL233969 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33N9O2 |
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| Mol. Mass. | 539.6314 |
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| SMILES | C[C@H](Nc1nc(nc2n(C)c(cc12)C(=O)NCCCN1CCOCC1)-n1cnc2ccncc12)c1ccccc1 |
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| Structure | 
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