Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50244290 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_555345 (CHEMBL954745) |
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IC50 | 6200±n/a nM |
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Citation | Schuster, D; Nashev, LG; Kirchmair, J; Laggner, C; Wolber, G; Langer, T; Odermatt, A Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem51:4188-99 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50244290 |
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n/a |
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Name | BDBM50244290 |
Synonyms: | 2-(2-bromo-6-ethoxy-4-((3-mercapto-5-methyl-4H-pyrazol-4-ylamino)methyl)phenoxy)-N-cyclohexylacetamide | CHEMBL469911 |
Type | Small organic molecule |
Emp. Form. | C21H29BrN4O3S |
Mol. Mass. | 497.449 |
SMILES | CCOc1cc(CNc2c(C)[nH][nH]c2=S)cc(Br)c1OCC(=O)NC1CCCCC1 |
Structure |
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