| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
|---|
| Ligand | BDBM50243154 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_491608 (CHEMBL945184) |
|---|
| IC50 | 50±n/a nM |
|---|
| Citation |  Wu, D; Pontillo, J; Ching, B; Hudson, S; Gao, Y; Fleck, BA; Gogas, K; Wade, WS Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorg Med Chem Lett18:4224-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent serotonin transporter |
|---|
| Name: | Sodium-dependent serotonin transporter |
|---|
| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 70322.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31645 |
|---|
| Residue: | 630 |
|---|
| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
|
|
|
|---|
| BDBM50243154 |
|---|
| n/a |
|---|
| Name | BDBM50243154 |
|---|
| Synonyms: | CHEMBL487690 | cis-3-(4-chlorophenoxy)-N,N-dimethyl-2,3-dihydro-1H-inden-1-amine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18ClNO |
|---|
| Mol. Mass. | 287.784 |
|---|
| SMILES | CN(C)[C@@H]1C[C@H](Oc2ccc(Cl)cc2)c2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
