| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate lyase |
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| Ligand | BDBM50276442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_540910 (CHEMBL1026584) |
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| IC50 | 89000±n/a nM |
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| Citation |  Lee, HS; Yoon, KM; Han, YR; Lee, KJ; Chung, SC; Kim, TI; Lee, SH; Shin, J; Oh, KB 5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp. Bioorg Med Chem Lett19:1051-3 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate lyase |
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| Name: | Isocitrate lyase |
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| Synonyms: | ACEA_CANAX | ICL1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61398.95 |
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| Organism: | Candida albicans |
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| Description: | ChEMBL_972063 |
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| Residue: | 550 |
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| Sequence: | MPYTPIDIQKEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKINHPSSQQA
DKLFKLLETHDADKTVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLA
DYPMDTVPNKVEHLWFAQLFHDRKQREERLTLSKEERAKTPYIDFLRPIIADADTGHGGI
TAIIKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGS
NLLAVARTDSEAATLITSTIDHRDHYFIIGATNPEAGDLAALMAEAESKGIYGNELAAIE
SEWTKKAGLKLFHEAVIDEIKNGNYSNKDALIKKFTDKVNPLSHTSHKEAKKLAKELTGK
DIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYAQAKEFADGVKA
AVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGKLGYVWQFITLAGLHTTALAVDDFSN
QYSQIGMKAYGQTVQQPEIEKGVEVVKHQKWSGATYIDGLLKMVSGGVTSTAAMGQGVTE
DQFKESKAKA
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| BDBM50276442 |
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| n/a |
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| Name | BDBM50276442 |
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| Synonyms: | CHEMBL459354 | hyrtiosin B |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12N2O4 |
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| Mol. Mass. | 320.2989 |
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| SMILES | Oc1ccc2[nH]cc(C(=O)C(=O)c3c[nH]c4ccc(O)cc34)c2c1 |
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| Structure | 
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