| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase HST2 |
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| Ligand | BDBM50304357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_606799 (CHEMBL1067344) |
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| IC50 | 6500±n/a nM |
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| Citation |  Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem17:7031-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase HST2 |
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| Name: | NAD-dependent protein deacetylase HST2 |
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| Synonyms: | HST2 | HST2_YEAST | NAD-dependent deacetylase HST2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39972.79 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_533704 |
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| Residue: | 357 |
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| Sequence: | MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKL
PYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTL
ERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPA
IVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPR
KVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDN
SKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
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| BDBM50304357 |
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| n/a |
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| Name | BDBM50304357 |
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| Synonyms: | 4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]chromen-3-yl ester | CHEMBL595128 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24O5 |
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| Mol. Mass. | 404.4551 |
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| SMILES | CCc1ccc(OCCCC(O)Oc2ccc3c(c2)oc(=O)c2ccccc32)cc1 |
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| Structure | 
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