| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase HST2 |
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| Ligand | BDBM50304351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_606805 (CHEMBL1068569) |
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| Ki | 43000±n/a nM |
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| Citation |  Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem17:7031-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase HST2 |
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| Name: | NAD-dependent protein deacetylase HST2 |
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| Synonyms: | HST2 | HST2_YEAST | NAD-dependent deacetylase HST2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39972.79 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_533704 |
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| Residue: | 357 |
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| Sequence: | MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKL
PYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTL
ERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPA
IVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPR
KVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDN
SKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
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| BDBM50304351 |
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| n/a |
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| Name | BDBM50304351 |
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| Synonyms: | 6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol | CHEMBL592963 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19NO3 |
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| Mol. Mass. | 261.3163 |
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| SMILES | COCC#CC1N(C)CCc2cc(OC)c(O)cc12 |
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| Structure | 
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