Reaction Details |
| Report a problem with these data |
Target | Caspase-3 |
---|
Ligand | BDBM50338489 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_728312 (CHEMBL1687572) |
---|
IC50 | 18±n/a nM |
---|
Citation | Jiang, Y; Hansen, TV Isatin 1,2,3-triazoles as potent inhibitors against caspase-3. Bioorg Med Chem Lett21:1626-9 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Caspase-3 |
---|
Name: | Caspase-3 |
Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
Type: | Hydrolase; heterotetramer of two heterodimers |
Mol. Mass.: | 31607.55 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 277 |
Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
|
|
|
BDBM50338489 |
---|
n/a |
---|
Name | BDBM50338489 |
Synonyms: | (S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-((1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione | CHEMBL1683176 |
Type | Small organic molecule |
Emp. Form. | C24H22F3N5O5S |
Mol. Mass. | 549.522 |
SMILES | COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(Cc3cn(nn3)-c3ccc(cc3)C(F)(F)F)C(=O)C(=O)c2c1 |r| |
Structure |
|