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TargetPeptidyl-prolyl cis-trans isomerase FKBP4
LigandBDBM50388295
Substrate/Competitorn/a
Meas. Tech.ChEMBL_829706 (CHEMBL2061146)
IC50>100000±n/a nM
Citation Gopalakrishnan, RKozany, CWang, YSchneider, SHoogeland, BBracher, AHausch, F Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52. J Med Chem55:4123-31 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP4
Name:Peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms:FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52
Type:PROTEIN
Mol. Mass.:51793.87
Organism:Homo sapiens (Human)
Description:ChEMBL_154482
Residue:459
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGW
LLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPP
KIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKD
KLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPN
AELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWL
EYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRG
EAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAE
EENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50388295
n/a
NameBDBM50388295
Synonyms:CHEMBL2058791
TypeSmall organic molecule
Emp. Form.C23H26N2O7S2
Mol. Mass.506.592
SMILESCOc1ccc(OCCOC(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc3ncsc3c2)cc1OC |r|
Structure
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