| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50389542 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_832555 (CHEMBL2067441) |
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| IC50 | 117.49±n/a nM |
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| Citation |  Agelis, G; Resvani, A; Durdagi, S; Spyridaki, K; Tumová, T; Slaninová, J; Giannopoulos, P; Vlahakos, D; Liapakis, G; Mavromoustakos, T; Matsoukas, J The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives. Eur J Med Chem55:358-74 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
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| Type: | Protein |
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| Mol. Mass.: | 41080.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30556 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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| BDBM50389542 |
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| n/a |
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| Name | BDBM50389542 |
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| Synonyms: | CHEMBL2063981 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23BrN6O |
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| Mol. Mass. | 467.362 |
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| SMILES | CCCCc1c(Br)nc(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |
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| Structure | 
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