| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily A member 1 |
|---|
| Ligand | BDBM50390459 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_835270 (CHEMBL2071976) |
|---|
| IC50 | 5011.87±n/a nM |
|---|
| Citation |  Vallin, KS; Sterky, KJ; Nyman, E; Bernström, J; From, R; Linde, C; Minidis, AB; Nolting, A; Närhi, K; Santangelo, EM; Sehgelmeble, FW; Sohn, D; Strindlund, J; Weigelt, D N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor. Bioorg Med Chem Lett22:5485-92 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily A member 1 |
|---|
| Name: | Transient receptor potential cation channel subfamily A member 1 |
|---|
| Synonyms: | ANKTM1 | Ankyrin-like with transmembrane domains protein 1 | TRPA1 | TRPA1_HUMAN | Transformation-sensitive protein p120 | Transient receptor potential cation channel subfamily A member 1 (TRPA1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 127514.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75762 |
|---|
| Residue: | 1119 |
|---|
| Sequence: | MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
|
|
|
|---|
| BDBM50390459 |
|---|
| n/a |
|---|
| Name | BDBM50390459 |
|---|
| Synonyms: | CHEMBL2071591 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H21ClN2O3 |
|---|
| Mol. Mass. | 312.792 |
|---|
| SMILES | CC(C)C(NC(=O)OC(C)(C)C)C(=O)c1ccc(Cl)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
