Reaction Details |
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Target | Corticotropin-releasing factor receptor 1 |
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Ligand | BDBM50389537 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_855115 (CHEMBL2160873) |
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IC50 | 184±n/a nM |
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Citation | Takeda, K; Terauchi, T; Hashizume, M; Shikata, K; Taguchi, R; Murata-Tai, K; Fujisawa, M; Takahashi, Y; Shin, K; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists. Bioorg Med Chem20:6559-78 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Corticotropin-releasing factor receptor 1 |
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Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
Type: | Enzyme |
Mol. Mass.: | 50744.31 |
Organism: | Homo sapiens (Human) |
Description: | P34998 |
Residue: | 444 |
Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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BDBM50389537 |
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n/a |
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Name | BDBM50389537 |
Synonyms: | CHEMBL2063380 |
Type | Small organic molecule |
Emp. Form. | C24H30N2O3 |
Mol. Mass. | 394.5066 |
SMILES | CCN(CC)c1ccc(C)c2nc(ccc12)-c1c(OC)cc(COC)cc1OC |
Structure |
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