Reaction Details |
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Target | Growth hormone secretagogue receptor type 1 |
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Ligand | BDBM50395757 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_860218 (CHEMBL2169159) |
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IC50 | >10000±n/a nM |
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Citation | Puleo, L; Marini, P; Avallone, R; Zanchet, M; Bandiera, S; Baroni, M; Croci, T Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists. Bioorg Med Chem20:5623-36 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Growth hormone secretagogue receptor type 1 |
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Name: | Growth hormone secretagogue receptor type 1 |
Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
Type: | Receptor |
Mol. Mass.: | 41334.57 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
Residue: | 366 |
Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50395757 |
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n/a |
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Name | BDBM50395757 |
Synonyms: | CHEMBL2164824 |
Type | Small organic molecule |
Emp. Form. | C21H23Cl3N4O2 |
Mol. Mass. | 469.792 |
SMILES | CN(C)CCN(C)CC(=O)NC1(C(=O)Nc2cc(Cl)c(Cl)cc12)c1ccc(Cl)cc1 |
Structure |
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