Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50397131 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_864175 (CHEMBL2175124) |
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IC50 | 59±n/a nM |
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Citation | Crawford, JJ; Kenny, PW; Bowyer, J; Cook, CR; Finlayson, JE; Heyes, C; Highton, AJ; Hudson, JA; Jestel, A; Krapp, S; Martin, S; Macfaul, PA; McDermott, BP; McGuire, TM; Morley, AD; Morris, JJ; Page, KM; Ribeiro, LR; Sawney, H; Steinbacher, S; Smith, C; Dossetter, AG Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors. J Med Chem55:8827-37 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50397131 |
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n/a |
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Name | BDBM50397131 |
Synonyms: | CHEMBL2171996 |
Type | Small organic molecule |
Emp. Form. | C24H32N4O4S |
Mol. Mass. | 472.6 |
SMILES | C[C@H]1CN(CCN1C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(CC1)C#N)c1ccc(cc1)S(C)(=O)=O |r| |
Structure |
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