| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tubulin alpha-1A chain |
|---|
| Ligand | BDBM50014853 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_212206 (CHEMBL817769) |
|---|
| IC50 | 1584.89±n/a nM |
|---|
| Citation |  Zhang, SX; Feng, J; Kuo, SC; Brossi, A; Hamel, E; Tropsha, A; Lee, KH Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis. J Med Chem43:167-76 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tubulin alpha-1A chain |
|---|
| Name: | Tubulin alpha-1A chain |
|---|
| Synonyms: | TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50049.25 |
|---|
| Organism: | Sus scrofa (Pig) |
|---|
| Description: | P02550 |
|---|
| Residue: | 451 |
|---|
| Sequence: | MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
|
|
|
|---|
| BDBM50014853 |
|---|
| n/a |
|---|
| Name | BDBM50014853 |
|---|
| Synonyms: | CHEMBL277998 | N-((S)-3-Hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide | N-(3-Hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide | cid_434973 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23NO5S |
|---|
| Mol. Mass. | 401.476 |
|---|
| SMILES | COc1c(O)cc2CC[C@H](NC(C)=O)c3cc(=O)c(SC)ccc3-c2c1OC |
|---|
| Structure | 
|
|---|
Search and Browse
