| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Egl nine homolog 1 |
|---|
| Ligand | BDBM50244093 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_934087 (CHEMBL2318589) |
|---|
| IC50 | >10000000±n/a nM |
|---|
| Citation |  Leung, IK; Demetriades, M; Hardy, AP; Lejeune, C; Smart, TJ; Szöllössi, A; Kawamura, A; Schofield, CJ; Claridge, TD Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. J Med Chem56:547-55 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Egl nine homolog 1 |
|---|
| Name: | Egl nine homolog 1 |
|---|
| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46035.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9GZT9 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
|
|
|
|---|
| BDBM50244093 |
|---|
| n/a |
|---|
| Name | BDBM50244093 |
|---|
| Synonyms: | 1-hydroxypropane-1,2,3-tricarboxylate | isocitrate | isocitrate(3-) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H5O7 |
|---|
| Mol. Mass. | 189.1013 |
|---|
| SMILES | OC(C(CC([O-])=O)C([O-])=O)C([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
