| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
|---|
| Ligand | BDBM50431942 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_953679 (CHEMBL2352583) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Atobe, M; Maekawara, N; Ishiguro, N; Sogame, S; Suenaga, Y; Kawanishi, M; Suzuki, H; Jinno, N; Tanaka, E; Miyoshi, S A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors. Bioorg Med Chem Lett23:2106-10 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 72 kDa type IV collagenase |
|---|
| Name: | 72 kDa type IV collagenase |
|---|
| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 73870.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08253 |
|---|
| Residue: | 660 |
|---|
| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
|
|
|
|---|
| BDBM50431942 |
|---|
| n/a |
|---|
| Name | BDBM50431942 |
|---|
| Synonyms: | CHEMBL2347847 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12N2O3S2 |
|---|
| Mol. Mass. | 332.397 |
|---|
| SMILES | OC(=O)Cc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
