| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-alpha |
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| Ligand | BDBM50434252 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_960948 (CHEMBL2388708) |
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| EC50 | >30000±n/a nM |
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| Citation |  Dubernet, M; Duguet, N; Colliandre, L; Berini, C; Helleboid, S; Bourotte, M; Daillet, M; Maingot, L; Daix, S; Delhomel, JF; Morin-Allory, L; Routier, S; Walczak, R Identification of New Nonsteroidal ROR? Ligands; Related Structure-Activity Relationships and Docking Studies. ACS Med Chem Lett4:504-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-alpha |
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| Name: | Nuclear receptor ROR-alpha |
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| Synonyms: | NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58976.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_101591 |
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| Residue: | 523 |
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| Sequence: | MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVT
KKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRT
SRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAE
PLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIK
PEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITW
QTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS
LEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEI
ALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRAL
CGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
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| BDBM50434252 |
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| n/a |
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| Name | BDBM50434252 |
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| Synonyms: | CHEMBL2385730 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N2O5S |
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| Mol. Mass. | 442.528 |
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| SMILES | COc1cc(ccc1OCc1ccccc1)C1NC(=O)N=C(C)C1C(=O)OCCSC |t:22| |
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| Structure | 
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