Reaction Details |
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Target | Cathepsin D |
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Ligand | BDBM50437542 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_974167 (CHEMBL2411009) |
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IC50 | 2.0±n/a nM |
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Citation | Pennington, LD; Whittington, DA; Bartberger, MD; Jordan, SR; Monenschein, H; Nguyen, TT; Yang, BH; Xue, QM; Vounatsos, F; Wahl, RC; Chen, K; Wood, S; Citron, M; Patel, VF; Hitchcock, SA; Zhong, W Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity. Bioorg Med Chem Lett23:4459-64 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin D |
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Name: | Cathepsin D |
Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
Type: | Enzyme |
Mol. Mass.: | 44551.72 |
Organism: | Homo sapiens (Human) |
Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
Residue: | 412 |
Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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BDBM50437542 |
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n/a |
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Name | BDBM50437542 |
Synonyms: | CHEMBL2407492 |
Type | Small organic molecule |
Emp. Form. | C35H44N4O4 |
Mol. Mass. | 584.7483 |
SMILES | CC(C)(C)Cc1cnc2OC3(CCC3)C[C@H](NC[C@@H](O)[C@@H]3Cc4cccc(CCCn5cc(ccc5=O)C(=O)N3)c4)c2c1 |r| |
Structure |
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