| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50437546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_974167 (CHEMBL2411009) |
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| IC50 | 4.3±n/a nM |
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| Citation |  Pennington, LD; Whittington, DA; Bartberger, MD; Jordan, SR; Monenschein, H; Nguyen, TT; Yang, BH; Xue, QM; Vounatsos, F; Wahl, RC; Chen, K; Wood, S; Citron, M; Patel, VF; Hitchcock, SA; Zhong, W Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity. Bioorg Med Chem Lett23:4459-64 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 44551.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
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| Residue: | 412 |
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| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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| BDBM50437546 |
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| n/a |
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| Name | BDBM50437546 |
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| Synonyms: | CHEMBL2407487 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H47N3O3 |
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| Mol. Mass. | 533.7446 |
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| SMILES | CC(C)(C)Cc1cnc2OC3(CCC3)C[C@H](NC[C@@H](O)[C@@H]3Cc4cccc(CCCCCCC(=O)N3)c4)c2c1 |r| |
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| Structure | 
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