| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50443729 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1279690 (CHEMBL3094880) |
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| IC50 | 347±n/a nM |
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| Citation |  Yang, SM; Tang, Y; Zhang, R; Lu, H; Kuo, GH; Gaul, MD; Li, Y; Ho, G; Conway, JG; Liang, Y; Lenhard, JM; Demarest, KT; Murray, WV 4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs. Bioorg Med Chem Lett23:6773-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41485.97 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07308 |
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| Residue: | 358 |
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| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
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| BDBM50443729 |
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| n/a |
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| Name | BDBM50443729 |
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| Synonyms: | CHEMBL3093879 | US9238658, 62 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25FN4OS |
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| Mol. Mass. | 400.513 |
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| SMILES | Fc1ccc2CCN(C3CCN(CC3)C(=O)Nc3nc4CCCCc4s3)c2c1 |
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| Structure | 
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