| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
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| Ligand | BDBM27507 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1467916 (CHEMBL3413120) |
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| IC50 | 6300±n/a nM |
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| Citation |  Yang, T; Chen, X; Jin, HX; Sethi, G; Go, ML Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity. Eur J Med Chem92:145-55 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-2 |
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| Name: | NAD-dependent protein deacetylase sirtuin-2 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 43172.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 389 |
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| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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| BDBM27507 |
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| n/a |
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| Name | BDBM27507 |
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| Synonyms: | 3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacinamide | nicotinamide | pyridine-3-carboxamide |
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| Type | n/a |
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| Emp. Form. | C6H6N2O |
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| Mol. Mass. | 122.1246 |
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| SMILES | NC(=O)c1cccnc1 |
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| Structure | 
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