| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 1 |
|---|
| Ligand | BDBM50102670 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1443096 (CHEMBL3380802) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Doig, P; Boriack-Sjodin, PA; Dumas, J; Hu, J; Itoh, K; Johnson, K; Kazmirski, S; Kinoshita, T; Kuroda, S; Sato, TO; Sugimoto, K; Tohyama, K; Aoi, H; Wakamatsu, K; Wang, H Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorg Med Chem22:6256-69 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interleukin-1 receptor-associated kinase 1 |
|---|
| Name: | Interleukin-1 receptor-associated kinase 1 |
|---|
| Synonyms: | IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 76536.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51617 |
|---|
| Residue: | 712 |
|---|
| Sequence: | MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
|
|
|
|---|
| BDBM50102670 |
|---|
| n/a |
|---|
| Name | BDBM50102670 |
|---|
| Synonyms: | CHEMBL3343046 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18N2O4 |
|---|
| Mol. Mass. | 362.3786 |
|---|
| SMILES | COc1cc(ccc1O)C(=O)Nc1ccc(NC(=O)c2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
