| Reaction Details |
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 | Report a problem with these data |
| Target | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Ligand | BDBM50154370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1560761 (CHEMBL3778458) |
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| EC50 | 1020±n/a nM |
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| Citation |  Tarver, JE; Pabba, PK; Barbosa, J; Han, Q; Gardyan, MW; Brommage, R; Thompson, AY; Schmidt, JM; Wilson, AG; He, W; Lombardo, VK; Carson, KG Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett26:1525-8 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Palmitoleoyl-protein carboxylesterase NOTUM |
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| Name: | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Synonyms: | NOTUM_MOUSE | Notum | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56587.82 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_116720 |
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| Residue: | 503 |
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| Sequence: | MGGEVRVLLLLGLLHWVGGSEGRKTWRRRGQQPPQPPPPPPLPQRAEVEPGAGQPVESFP
LDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKE
SKGSRRWLLFLEGGWYCFNRENCDSRYSTMRRLMSSKDWPHTRTGTGILSSQPEENPHWW
NANMVFIPYCSSDVWSGASPKSDKNEYAFMGSLIIQEVVRELLGKGLSGAKVLLLAGSSA
GGTGVLLNVDRVAELLEELGYPSIQVRGLADSGWFLDNKQYRRSDCIDTINCAPTDAIRR
GIRYWSGMVPERCQRQFKEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTG
QPVQEGQWLYIQNLGRELRGTLKDVQASFAPACLSHEIIIRSYWTDVQVKGTSLPRALHC
WDRSFHDSHKASKTPMKGCPFHLVDSCPWPHCNPSCPTIRDQFTGQEMNVAQFLMHMGFD
VQTVAQQQGMEPSKLLGMLSNGN
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| BDBM50154370 |
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| n/a |
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| Name | BDBM50154370 |
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| Synonyms: | CHEMBL1689356 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10N2O2S2 |
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| Mol. Mass. | 254.329 |
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| SMILES | Cc1sc2ncnc(SCC(O)=O)c2c1C |
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| Structure | 
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