Reaction Details |
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Target | Dipeptidyl peptidase 1 |
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Ligand | BDBM50195239 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1617560 (CHEMBL3859629) |
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IC50 | 3.2±n/a nM |
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Citation | Connolly, S; Lönn, H; Käck, H; Van de Poël, A; Dahl, G; Doyle, K; Gardiner, P; Root, J; Wikell, C; Johannesson, P; Stenvall, K; Swallow, S Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J Med Chem59:9457-9472 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dipeptidyl peptidase 1 |
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Name: | Dipeptidyl peptidase 1 |
Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
Type: | Enzyme |
Mol. Mass.: | 51857.28 |
Organism: | Homo sapiens (Human) |
Description: | P53634 |
Residue: | 463 |
Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
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BDBM50195239 |
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n/a |
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Name | BDBM50195239 |
Synonyms: | CHEMBL3972563 | US10287258, Example 29 | US10669245, Example 29 | US11117874, Example 29 | US11655221, Example 29 | US11680049, Example 29 | US20230278969, Example 29 |
Type | Small organic molecule |
Emp. Form. | C23H24N4O3S |
Mol. Mass. | 436.527 |
SMILES | Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| |
Structure |
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